Dental caries and periodontitis, although generally not life threatening, are nevertheless of significant importance. An understanding of the molecular nature of these diseases could aid the development of novel methods of prevention and control, and increase our knowledge of their etiology. The identification of virulence factors in oral bacteria could lead to the development of vaccines direc...

The biotype and virulence of skin isolates of Candida parapsilosis were compared with blood isolates of the same fungus. Morphotype, resistotype, and electrophoretic karyotype determinations did not reveal any special cluster with a unique or dominant pathogenic feature among all of the isolates, regardless of their source. However, all cutaneous isolates had uniformly elevated secretory aspart...

There is growing evidence that the sugar N-acetylglucosamine (GlcNAc) plays diverse roles in cell signaling pathways that impact the virulence properties of microbes and host cells. GlcNAc is already well known as a ubiquitous structural component at the cell surface that forms part of bacterial cell wall peptidoglycan, cell wall chitin in fungi and parasites, and extracellular matrix glycosami...

extra-intestinal pathogenic escherichia coli (expec) strains are divided into uropathogenic e. coli (upec), strains causing neonatal meningitis and septicaemic e. coli. the most common pathotype of expec is found among patients with urinary tract infection (uti), defined as upec. these bacteria are responsible for >90% of cases of uti and are often found amongst the faecal flora of the same hos...

helicobacter pylori infection is a common gastrointestinal infection that can cause pathological effects, increase oxidative stress and induce an inflammatory response in gastric mucosa. inflammatory aspects may prompt the production of radical oxygen substance (ros) which may damage cells and release 8-hydroxydyoxyguanosine (8-ohdg) to serum. in this study, we evaluate the prevalence of h. pyl...

conclusions the results showed that e. coli isolated from patients with uti had eight virulence factors with high frequencies. moreover, these results alleged a direct connection between virulence factors and antimicrobial resistance in e. coli. results the frequency of virulence factors papc, afa, sfa/foc, fimh, hly, neuc, ibea, and iucc were 53.3%, 51.7%, 53.3%, 56.7%, 23.3%, 31.7%, 20%, and ...

Background: In the last decade, importance of hetero-pathogenic enteroaggregative Shiga-toxin-producing E. coli for public health has increased. Recently, we described genetic background EAHEC O181:H4 strain ST678 carrying stx2 gene in prophage and five plasmids, including plasmid-carrying aggR aaiC genes. Here, present morphological enzymatic characteristics this strain, as well susceptibility...

In 1930, Felix d’Herelle wrote “. . .the actions and reactions are not solely between these two beings, man and bacterium, for the bacteriophage also intervenes; a third living being and, hence, a third variable is introduced” (19). The contribution of bacteriophages to the pathogenicity of their bacterial hosts began to be uncovered as early as 1927, when Frobisher and Brown discovered that no...

the main features of enteroaggregative escherichia coli (eaec) pathogenesis include attachment of bacteria to the intestinal mucosa, production of various toxins and cytotoxins, and stimulation of mucosal inflammation. ‘virulence’ genes encode these features. comparison of different eaec isolates has shown that the virulence gene content of these isolates varies considerably. the heterogeneity ...

isoniazid, is the only antituberculous drug for which the relation between lack of virulence and acquisition of resistance was associated. inh-resistant mutants were shown to contain defective katg gene. classical studies showed that inh-resistant south indian isolates have lower virulence in guinea pigs and higher susceptibility to h2o2. it is of interest to assess the virulence in south india...