Oncolytic virotherapy is the use of viruses to target a tumor for infection and lysis while leaving healthy cells uninfected. The history of viral oncology dates back to the turn of the 20th century when clinicians observed spontaneous regression of tumors after vaccination with attenuated viruses [1]. Experiments were done in the 1950s using Picornaviruses but soon fell out of favour to chemot...

In the past two decades, more than 20 viruses with selective tropism for tumor cells have been developed as oncolytic viruses (OVs) for treatments of a variety of malignancies. Of these viruses, eleven have been tested in human ovarian cancer models in preclinical studies. So far, nine phase I or II clinical trials have been conducted or initiated using four different types of OVs in patients w...

The aim of this work is to propose and analyze a new mathematical model formulated by fractional differential equations (FDEs) that describes the dynamics oncolytic M1 virotherapy. well-posedness proposed proved through existence, uniqueness, nonnegativity, boundedness solutions. Furthermore, we study all equilibrium points conditions needed for their existence. We also global stability these i...

We present a mathematical model based on ordinary differential equations to investigate the spatially homogeneous state of tumor growth under virotherapy. The emphasizes interaction among cells, oncolytic viruses, and host immune system that generates both innate adaptive responses. conduct rigorous equilibrium analysis derive threshold conditions determine or decay various scenarios. Numerical...

We report here the complete genome sequence of Sendai virus Moscow strain. Anecdotal evidence for the efficacy of oncolytic virotherapy exists for this strain. The RNA genome of the Moscow strain is 15,384 nucleotides in length and differs from the nearest strain, BB1, by 18 nucleotides and 11 amino acids.

About a century ago, shortly after viruses were recognized, occasional tumor regressions were documented after natural infections. This observation established the idea of using viruses to fight cancer [1]. Early virotherapy clinical trials based on natural viruses were poorly controlled, but recent ones based on modified viruses are subject to extensive monitoring of viral replication, gene ex...