b ackground: l eishmania is an intracellular parasite infecting humans and many wild and domestic animals. recent studies have suggested an important role for cytotoxic t cells against leishmania . peptide-based vaccines targeting short sequences derived from known immunogenic proteins have been shown to elicit cellular immune responses against disparate pathogens. m ethods: we predicted four h...

noroviruses (novs), an important pathogenic agent of foodborne illness, lead to acute and chronic gastroenteritis in humans of all ages and to travelers’ diarrhea. many genotypes exist in nature; gii.4 is widely known as the most predominant. outbreaks mostly occur in semi-closed settings. although the disease is self-limited to person, many cases have resulted in death, which has raised more c...

humoral immune response of vaccine-i (supermatent from sonicated sporulated oocyst), vaccine –ii (sediment from sonicated sporulated oocyst) and vaccine –iii (un-sonicated sporulated oocyst) against conccidiosis in chickens was determined by indirect haemagglutination (iha) test. iha antibody titre was significantly higher (p

mycoplasma agalactia was cultured in pplo broth medium supplemented with sterilized normal horse serum in fermentor. cultivation process continued at 37 ºc under aerobic conditions and growth was terminated after 26 hours cultured period with 2.2×109 mycoplasma per ml. samples were taken at different stages of growth. culture was inactivated with 0.04 %v/v formaldehyde and the vaccine was adjuv...

conclusions it has the potential to cause disseminated infection, and an increasing number of immunocompromised patients prone to disease and the suboptimal preventive potency of this vaccine suggest the need for a global attempt to review its benefits and disadvantages. results worldwide, a proportion of new cases with multidrug-resistant tb (mdr-tb) were reported at 3.5% in 2013 without a sig...

manufacturing new hepatitis b virus vaccines, specifically by the use of nanoparticles, is of high global interest. in this paper, a new biocompatible and biodegradable structure of nano-sized hepatitis b virus’ surface antigen (hbsag) was generated by conjugation with dendrimers, a low cost biodegradable and biocompatible polymer. the physicochemical properties of the conjugate were characteri...

context hepatitis b virus expanded program on immunization (epi) started on 1993 in iran. most surveys have assessed the level of response to vaccine by measuring the titers of anti-hbs. this meta- analysis aimed to summarize the iranian published data on the rate of vaccine-responders versus non-responders. moreover, the impact of variables such as age, gender, type of vaccine, etc. on the lev...

abstract: in order to study the effect of concomitant use of a probiotic with lactobacillus origin (primalac) and a coccidiosis vaccine (paracox-5) in experimental coccidial infection of broilers, 600 day old male broiler chickens were randomly divided into five groups of 120 with four replicates. groups three, four and five received probiotic , coccidiosis vaccine and probiotic + coccidiosis v...

introduction: epidermal growth factor receptor (egfr) has been shown to play a critical role in tumor cell growth and its overexpression has been observed in many epithelial tumors. in the field of cancer vaccine research, displaying the peptide mimotope on the surface of phage particles has shown promising results. methods: in this study using m13-pviii phage display system, two constructs wer...

herein, we described the first case of self-inoculation in a veterinarian with bovine johne’s disease(bjd) attenuated vaccine in iran that required medical attention. a needle-stick injury to the right thumb of ayoung veterinarian during vaccination of cattle with bjd vaccine resulted in an inflammation that not onlyfailed to resolve but also progressed to a lesion 2.5 cm in diameter. the usual...