A 23-year-old female presented with a reddish-brown dome-shaped hyperkeratotic nodule of 11 × 10 mm on the left lower leg. Dermoscopic examination demonstrated a prominent whitish scaly area with ring-like appearance, pinkish-white structureless areas, a few milia-like cysts, dotted and glomerular vessels, and light brown globules. The lesion was completely excised under the diagnosis of verruc...

background spitz nevus is an infrequent acquired melanocytic nevus. there is still a challenge for dermatopathologists in distinguishing spitz nevus from malignant melanoma particularly in adults since there is no immunohistochemistry or molecular markers which differentiate spitz nevus from melanoma. objectives the aim of this study is to make clear what clinico-histopathological features of s...

Epidermal nevus syndrome (ENS) is a term used to describe the occurrence of an epidermal nevus in association with other extra-cutaneous developmental anomalies, most commonly involving the nervous and musculoskeletal systems. The nevus is classified on the basis of the main component which may be keratinocytic, sebaceous, follicular, apocrine, or eccrine. Most patients who present with ENS is ...

Epidermal nevi are congenital hamartomas of embryonal ectodermal origin classified on the basis of their main component. The compone keratinocytic. An estimated 1/3 of individuals with epidermal nevi have involvement of other organ systems; hence this condition is considered to be epidermal nevus syndrome. Solomon defined epidermal nevus syndrome as a sporadic neuro in the skin, brain, eyes and...

Linear epidermal nevus is an uncommon diagnosis of benign lesions of the oral cavity. It is characterized by a congenital malformation arising from the ectoderm cells, which are arranged according to a typical linear configuration known as Blaschko's lines. We report a case of linear epidermal nevus of oral cavity in a 51-year-old lady or woman. The linear epidermal nevus of the oral cavity, al...

Porokeratoses are uncommon hereditary or acquired keratinization disorders due to abnormal clones of keratinocytes in the epidermis. Porokeratoses have several clinical features which may occur simultaneously. A rare type is verrucous porokeratosis (VPK). Herein, we present a 47-year-old man with a 4-year history of perianal verrucous lesions and one year history of annular pruritic lesions on ...

A one year-old girl was referred to our dermatology department for assessment of an asymptomatic congenital pigmented lesion on the right posterior flank. Medical history was unremarkable. Dermatologic examination revealed a 30×10 mm homogeneous dark brown plaque with a verrucous surface, which was diagnosed as medium-sized CMN. After seven years of follow-up, the nevus had enlarged proportiona...

The epidermal nevus syndrome (ENS) is an uncommon neurocutaneous disorder in which epidermal nevi are found in association with congenital abnormalities of the brain, eye, and/or skeleton. The association of epidermal nevi and neurologic abnormalities was comprehensively described by Schimmelpenning in 1957. Pavone et al. (1991) identified a homogeneous variant of ENS with hemimegalencephaly, g...