BACKGROUND AND PURPOSE Impairment of cerebrovascular autoregulation may promote secondary brain injury in acute brain insults. Until now, only limited data are available on autoregulation in patients with spontaneous intracerebral hemorrhage. In the current study, we aimed to investigate cerebrovascular reactivity and its significance for outcome in spontaneous intracerebral hemorrhage. METHO...

BACKGROUND AND PURPOSE Acute hypoxia is associated with impairment of cerebral autoregulation (CA), but it is unclear if altered CA during prolonged hypoxia is pivotal to the development of cerebral pathology, such as that seen in acute mountain sickness (AMS). This investigation evaluated relationship between CA and AMS over 9 hours of hypobaric hypoxia. METHODS Fifty-five subjects (41 males...

Background: Hot flash is considered to be an early and common symptom of menopause. This symptom can interfere with the social and personal life of women; therefore, it demands a secure and effective intervention. Therefore, the present study aimed to determine the impact of black cohosh (Cimicifugaracemosa or actaearacemosa) on vasomotor symptoms in postmenopausal women. Materials and Methods:...

Aim: To investigate the effect of adding oophorectomy on patients who underwent abdominal hysterectomy in perimenopausal period menopause, sexual function and mental status. Materials Methods: The study was designed prospectively. Women total bilateral salpingectomy (TAH+BS) salpingo-ophorectomy (TAH+BSO) for benign indications were included study. Three months after surgery, menopausal symptom...

BACKGROUND AND PURPOSE We explored the association between transcranial Doppler hemodynamic parameters and the risk of stroke in the general population. METHODS At baseline, we assessed mean flow velocity, peak systolic flow velocity, end diastolic flow velocity, and vasomotor reactivity with transcranial Doppler in 2022 Rotterdam Study participants aged 61 years and over in both middle cereb...

We recently introduced model-based "physiomarkers" of dynamic cerebral autoregulation and CO2 vasomotor reactivity as an aid for diagnosis of early-stage Alzheimer's disease (AD) [1], where significant impairment of dynamic vasomotor reactivity (DVR) was observed in early-stage AD patients relative to age-matched controls. Milder impairment of DVR was shown in patients with amnestic mild cognit...