نتایج جستجو برای: vasculo

تعداد نتایج: 144  

Journal: :Frontiers in bioscience : a journal and virtual library 2008
Ann L B Seynhaeve Alexander M M Eggermont Timo L M ten Hagen

Growth of solid tumors depends largely on the development of a functional vasculature, which has been the focus in anti-tumor therapy since Folkman in 1971 proposed that prohibiting the formation of new vessels could inhibit tumor growth. The recognition of the tumor vascular bed as an important target led to the development of 3 vascular-targeted strategies. I) The anti-angiogenesis strategy t...

2015
Youness Sasbou Mohammed Boussaidane

L'ostéochondrome ou exostose est la tumeur osseuse primaire bénigne la plus fréquente, elle contient à la fois de l'os et du cartilage et siège le plus souvent au niveau des métaphyses des os longs. Ces tumeurs sont le plus souvent asymptomatiques, en fonction de leur taille, leur emplacement et de leur localisation; leur siège au niveau du fémur proximal est rarement rencontré car la plupart s...

Journal: :Oncology reports 2012
Hu He Chao Shi Niu Ming Wu Li

Glioblastoma multiforme (GBM) is the most lethal type of brain tumor. The formation of abnormal, dysfunctional tumor vasculature and glioblastoma stem-like cells (GSCs) are believed to be the major components of the inability to treat these tumors effectively. We analyzed 70 glioblastoma samples by immunohistochemistry and double immunofluorescenc...

2016
Nadine Dietrich Matthias Kolibabka Stephanie Busch Petra Bugert Ulrike Kaiser Jihong Lin Thomas Fleming Michael Morcos Thomas Klein Andrea Schlotterer Hans-Peter Hammes

BACKGROUND/AIMS Dipeptidyl peptidase 4 (DPP4) inhibitors improve glycemic control in type 2 diabetes, however, their influence on the retinal neurovascular unit remains unclear. METHODS Vasculo- and neuroprotective effects were assessed in experimental diabetic retinopathy and high glucose-cultivated C. elegans, respectively. In STZ-diabetic Wistar rats (diabetes duration of 24 weeks), DPP4 a...

Journal: :Blood 2013
Vincenzo Brancaleone Thomas Gobbetti Nicolas Cenac Pauline le Faouder Bartomeu Colom Roderick J Flower Nathalie Vergnolle Sussan Nourshargh Mauro Perretti

Endogenous protective pathways mitigate the overshooting of inflammation after sterile or infectious injury. Here we report that formyl peptide receptor 2 (Fpr2/3) null mice display a major phenotype with exacerbated vascular inflammation observed postischemia reperfusion (IR) injury of the mesenteric artery, characterized by marked neutrophil adhesion and extravasation as visualized by intravi...

Journal: :European Heart Journal 2022

Abstract Background Several strategies based on immune checkpoint inhibitors (ICIs) have been developed or are under investigation for cancer therapy, opening to advantages in outcomes. However, several ICIs-induced side effects emerged these patients, especially a rare but clinically significant cardiotoxicity with high rate of mortality. Purpose We analyzed the differential vasculo and Pembro...

Journal: :International journal of advanced research 2022

Introduction: Deafness is defined as hearing impairments that can occur at any age and be of genetic or idiopathic origin. They both abruptly gradually. The aim this work to underline the diagnostic above all etiological contribution spiral CT MRI during deafness, which makes it possible orient therapeutic conduct. Materials methods: We conducted a prospective on patients explored in radiology ...

Journal: :Alzheimers & Dementia 2023

Background Enlarged perivascular spaces (EPVS), quantified on brain imaging, can reflect structural changes of blood vessels or the surrounding fluid filled spaces. EPVS measures are emerging as promising biomarkers cerebral small vessel disease, especially in dementia research. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a vascular ne...

Journal: :Advances and technical standards in neurosurgery 2012
M Sindou M Messerer J Alvernia G Saint-Pierre

Knowledge of the pathological diagnosis before deciding the best strategy for treating parasellar lesions is of prime importance, due to the relative high morbidity and side-effects of open direct approaches to this region, known to be rich in important vasculo-nervous structures. When imaging is not evocative enough to ascertain an accurate pathological diagnosis, a percutaneous biopsy through...

Journal: :Journal of andrology 2004
François Giuliano

Penile erection is the ultimate vasculo-tissular response to an integrated and complex series of physiological processes elicited by psychological, neural, and hemodynamic events (Giuliano and Rampin, 2000; Saenz de Tejada, 2002). Upon sexual stimulation, penile erection, occurring in response to the activation of proerectile autonomic pathways, is greatly dependent on adequate inflow of blood ...

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