background: in recent years, neoadjuvant chemoradiation and subsequent surgical resection with total mesorectal excision has been shown to increase local control with decreased toxicity. neoadjuvant chemoradiotherapy is the standard treatment for locally advanced rectal cancer. in this study we evaluated the efficacy a cox-2 inhibitor on pathologic response, sphincter preservation and acute tox...

Traditional cross-sectional tumor imaging focuses solely on tumor morphology. With the introduction of targeted biological therapies in human trials, morphologic change may lag behind other physiologic measures of response on clinical images. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a new imaging method for assessing the physiologic state of tumor vascularity in vivo. D...

background and objectives: the most prevalent malignancy among women is known to be breast cancer (bc). several factors contribute to determining tumor prognosis and treatment strategies. in this study, the frequency and relevance of these factors are discussed. materials and methods: this cross-sectional study was carried out on 214 patients with bc, who referred to the cancer institute of im...

The phosphatidylinositol 3 -kinase (PI3k)/protein kinase B (PKB/Akt) signal transduction pathway plays a critical role in mediating endothelial cell survival and function during oxidative stress. The role of the PI3k/Akt signaling pathway in promoting cell viability was studied in vascular endothelial cells treated with ionizing radiation. Western blot analysis showed that Akt was rapidly phosp...

BACKGROUND New blood vessels formation is a critical step in tumor progression. Vascular density affects the clinical outcome and prognosis of malignant tumors. The aim of this study was to investigate the relation between the Vascular Endothelial Growth Factor (VEGF) expression and vascular density with the clinical and histopathologic features in oral squamous cell carcinoma (OSCC). METHODS...

Back Ground:The most important prognostic factor for squamous cell carcinoma (SCC) of oral is the status cervical lymph nodes. Cure rates drop by 50% with involvement regional nodes.The rate occult metastasis in clinically negative neck tongue cancers ranges from <20% to >30% depending on many predictors. Methods:The relationship clinical and histologic features primary tumor nodes was in...

  Background and Objectives: The most prevalent malignancy among women is known to be breast cancer (BC). Several factors contribute to determining tumor prognosis and treatment strategies. In this study, the frequency and relevance of these factors are discussed. Materials and Methods: This cross-sectional study was carried out on 214 patients with BC, who referred to the Cancer Institute of...

Fluctuations in tumor blood flow are common and attributed to factors such as vasomotion or local vascular structure, yet, because vessel structure and physiology are host-derived, animal strain of tumor propagation may further determine blood flow characteristics. In the present report, baseline and stress-altered tumor hemodynamics as a function of murine strain were studied using radiation-i...

Herein we report the management of a giant, high-grade and vascular carotid body tumor in a young woman. She presented with slowly progressive neck swelling. Vascular imaging revealed a left-sided, high-grade giant carotid body tumor (> 8cm).  The tumor was completely excised by caudocranial subadventitial dissection. Histology of the tumor revealed a characteristic Zellballen pattern of the le...