Vascular endothelial growth factors (VEGFs) are key mediator of retinal and choroidal neovascularization as well vascular leakage leading to macular edema. As such, VEGF plays an important role in mediating visually significant complications associated with common disorders such diabetic retinopathy, vein occlusion, age-related degeneration. Various drugs that inhibit (anti-VEGF therapies) have...

There is no evidence in the anesthetized dog that occlusion of one of the three coronary arteries leads to vasoconstriction in the vascular areas irrigated by the other two arteries. On the contrary, occlusion of one coronary artery appears to lead to a decrease in the resistance of the two adjacent vascular beds in most experiments. The mechanisms and the implications of this effect arc discus...

Retinal vein occlusion is an eye condition commonly seen by retinal specialists. It is second only to diabetic retinopathy as a cause of visual loss due to retinal vascular disease. There are two forms of retinal vein occlusion, branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO). While there are similarities in the pathogenesis and clinical nature of these two events...

We tested the hypothesis that blood flow through cerebral collateral vessels is lower in stroke-prone spontaneously hypertensive rats (SHRSP) than in normotensive Wistar-Kyoto rats (WKY) after occlusion of the middle cerebral artery and during maximal vasodilatation. Cerebral blood flow, measured with microspheres, was similar in adult male SHRSP and WKY under control conditions. In both strain...

BACKGROUND AND PURPOSE Phosphorylation of eNOS, an important post-translational modulator of its enzymatic activity, is reduced in diabetes mellitus. We hypothesized that modulation of eNOS phosphorylation could overcome diabetic vascular dysfunction and improves the outcome to stroke. METHODS We used the db/db mouse model of type 2 diabetes mellitus. We mated db/db mice with eNOS knock-in mi...

Rabbits fed a diet rich in cholesterol developed hypercholesterolemia and atheromas in the cornea, sclera, iris, ciliary body, and choroid, and a few synchysis scintillans in the vitreous. The fellow eye of these rabbits, in which one nasal vortex vein was occluded, developed far more severe changes in all the above-mentioned eye tissues, especially over the sector of the eye drained by the occ...

Vascular neurosurgery has been established through an on-site fellowship programme in Cameroon. With a less technically sophisticated basic equipment, high quality surgeries with good outcomes could still reached. We present two cases of big cavernous-segment aneurysms treated by distal ICA-occlusion awake surgery. To our knowledge these are the first neurosurgical procedures

Red blood cells (RBC) have unique flow-affecting properties--namely, aggregability, deformability and adherence to endothelial cells (EC)--which play major roles in blood flow. Under normal flow-induced shear stress RBC are dispersed, their adherence to EC is insignificant, and they are sufficiently deformable to enable tissue perfusion. However, in pathological conditions that are associated w...