Arteriolar arcades provide alternate pathways for blood flow after obstruction of arteries or arterioles such as occurs in stroke and coronary and peripheral vascular disease. When obstruction is prolonged, remaining vessels adjust their diameters chronically in response to altered hemodynamic and metabolic conditions. Here, the effectiveness of arcades in maintaining perfusion both immediately...

The antiallergic action of 2-[2-[4-(diphenylmethyl)-1-piperadinyl] ethoxy] benzoic acid maleate (ZCR-2060) was investigated on allergic cutaneous reactions and nasal vascular permeability in mice and rats. ZCR-2060 markedly inhibited immediate allergic cutaneous reactions, including passive cutaneous anaphylaxis (PCA) in rats and mice; histamine-, compound 48/80- and calcium ionophore A 23187-i...

OBJECTIVE The regulation of AMP-activated protein kinase (AMPK) is implicated in vascular biology because AMPK can phosphorylate endothelial NO synthase (eNOS). In this study, we investigate the regulation of the AMPK-eNOS pathway in vascular endothelial cells (ECs) by shear stress and the activation of aortic AMPK in a mouse model with a high level of voluntary running (High-Runner). METHODS...

Vascular occlusions are common structural modifications made by many plant species in response to pathogen infection. However, the functional role(s) of occlusions in host plant disease resistance/susceptibility remains controversial. This study focuses on vascular occlusions that form in stem secondary xylem of grapevines (Vitis vinifera) infected with Pierce's disease (PD) and the impact of o...

We employ a two-dimensional spectral element method to investigate the effect of various semi-circular blockages on the laminar flow between two flat plates. This simplified geometry has a general relevance to blocked flows, but more academically, also relates to work on the backward-facing step, presenting a qualitatively similar flow with a single, independent step, or blockage, parameter. Th...

A differential pressure transmitter with an orifice is widely used as a flowmeter. A major drawback of this type of flowmeter is blockage of the impulse line, which connects the differential pressure transmitter to the orifice tap. A diagnostic method based on the amplitude of pressure fluctuations in the impulse line can be used to diagnose a blockage in the steady state; however, there is the...

The process of freezing of water and blockage of pipes are summarized. Current research on freezing and its applications are briefly reviewed. Design concepts are introduced for doing work by utilizing pressures caused by ice blockage. Several conceptual designs are presented for experimental setups for the isostatic pressurization of thin walled tubes. Potential practical uses of pressures gen...

Left circumflex coronary blood flow (CBF) was measured in eight mongrel dogs with 8 MHz continuous wave Doppler flow transducers during classical aversive conditioning. The cardiovascular condition response consisted of significant (P less than 0.01) increases in: (1) mean aortic pressure (16.1%), (2) d(left ventricular pressure)/dt (64.2%), and (3) heart rate (63.2%). The coronary vascular res...