Vanillin has been reported to exhibit anti-invasive and antimetastatic activities by suppressing the enzymatic activity of matrix metalloproteinase-9 (MMP-9). However, the underlying mechanism of anti-invasive activity remains unclear so far. Herein we demonstrate that vanillin reduced 12-O-tetradecanoylphorbol13-acetate (TPA)-induced MMP-9 gelatinolytic activity and suppressed cell invasion th...

Vanillin dehydrogenase (VDH) is a crucial enzyme involved in the degradation of lignin-derived aromatic compounds. Herein, the VDH from Corynebacterium glutamicum was characterized. The relative molecular mass (Mr) determined by SDS-PAGE was ~51 kDa, whereas the apparent native Mr values revealed by gel filtration chromatography were 49.5, 92.3, 159.0 and 199.2 kDa, indicating the presence of d...

BACKGROUND The HCI-vanillin assay is a well-accepted method for determining tannin content in sorghum but is limited to small sample sets due to the time-consuming nature of the method. The objective was to develop an accurate and repeatable high-throughput 96-well plate assay for breeders to screen large sample sets of sorghum for tannin content. Validation of the high-throughput assay was tes...

To evaluate the effect of vanillin on the lipid profile of high fat diet induced hyperlipidemia in rats, the hyperlipidemia was induced by feeding cholesterol-rich high fat diet for 45 days in wistar rats of either sex. The reduction in the triglycerides and VLDL-C was significant at 200 & 400 mg/kg dose of vanillin compared to atorvastatin group. Reduction in total cholesterol was significant ...

In this work the possibility of producing vanillin through microbial bioconversion from ferulic acid obtained from the enzymatic hydrolysis of wheat bran has been explored. The biocatalyst employed was Escherichia coli JM109/pBB1, a recombinant strain containing the genes from Pseudomonas fluorescens BF13 for the transformation of ferulic acid into vanillin. The substrate of the bioconversion, ...

Numerous studies have focused on the influence of the social environment and the interactions between individuals on the collective decision-making of groups. They showed, for example, that attraction between individuals is at the origin of an amplification of individual preferences. These preferences may concern various environmental cues such as biomolecules that convey information about the ...