Structural elucidation of the active (DFG-Asp in) and inactive (DFG-Asp out) states of the TAM family of receptor tyrosine kinases is required for future development of TAM inhibitors as drugs. Herein we report a computational study on each of the three TAM members Tyro-3, Axl and Mer. DFG-Asp in and DFG-Asp out homology models of each one were built based on the X-ray structure of c-Met kinase...

The use of outsourcing is expanding rapidly. This chapter empirically tests a model of application development outsourcing acceptance based on the technology acceptance model (TAM). TAM-suggested perceived usefulness and ease of use mediate the effects of other variables on users’ attitudes towards a technology. The model tested in this chapter suggests that perceived usefulness and ease of use...

The Technology Acceptance Model (TAM) is a very important modelling approach in information technology research. In this study, an attempt is made to explain consumer acceptance of e-shopping by means of an extended model based on TAM. Perceived trust, perceived enjoyment, perceived information quality, perceived system quality and perceived service quality factors are added to the classical TA...

Mobile government systems allow users, ranging from individuals to businesses and government institutions, to have convenient access to information and government services. However, being able to assess users' acceptance to mobile government systems is one of the challenges that faces the adoption of these systems. Systems providers need to know in advance that systems would be accepted by the ...

Tumor-associated macrophages (TAMs) play an important role in the progression and prognostication of numerous cancers. However, the role and clinical significance of TAM markers in oral squamous cell carcinoma (OSCC) has not been elucidated. The present study was designed to investigate the correlation between the expression of TAM markers and pathological features in OSCC by tissue microarray....

results gelatin films exhibited good tensile strength and elongation at break, water solubility, swelling, and water vapor permeability. incorporation of tam into the gelatin films caused a significant decrease in tensile strength and swelling, and a significant increase in elongation at break, water solubility, water vapor permeability and whiteness of the films. gelatin films exhibited low an...

The Technology Acceptance Model (TAM) predicts the user acceptance of end-user applications by specifying causal relationships among external variables, belief and attitudinal constructs, and actual usage behavior. Although the perceived usefulness and perceived ease of use constructs have received much recent attention in the MIS literature, few studies have attempted to validate the fill TAM ...

A long-term treatment with tamoxifen (TAM) to women increases the risk of developing endometrial cancer. The cancer may result from genotoxic damage induced by this drug. In fact, TAM-DNA adducts were detected in the liver of rats treated with TAM and initiated to develop hepatocellular carcinomas. To explore the distribution and repair rate of TAM-DNA adducts, the level of TAM-DNA adducts in a...

1-[4-(2-Dimethylaminoethoxy)-phenyl]-1,2-diphenylbut-1-(Z)-ene (tamoxifen, TAM) is a nonsteroidal antiestrogen that has been commonly used for the prevention and treatment of estrogen receptor-positive breast cancer. TAM is extensively metabolized into several primary active metabolites including 4-hydroxy-TAM (4-OH-TAM) and endoxifen. Glucuronidation is the major phase II metabolic pathway imp...

This study examines the utility of three prospective models for understanding the continued IT usage behavior. The three models include: Expectation-Confirmation Model in IT Domain (ECM-IT), Technology Acceptance Model (TAM), and a hybrid model integrating TAM and ECM-IT (extended ECM-IT). Based on a survey of 1826 mobile Internet users, the LISREL analysis shows that all three models meet the ...