it has been shown that the immunophilin ligands have the special advantage in spinal cord repair. in this study, the effects of cyclosporine a (csa) on functional recovery and histological outcome were evaluated following spinal cord injury in rats. after spinal cord hemisection in thirty six adult female sprague-dawley rats (200- 250 g), treatment groups received csa (2.5 mg/kg i.p.) at 15min ...

Acetaminophen is determined in serum and urine samples by a rapid, sensitive, and precise chromatographic method without any pretreatment step in a C18 column using a pure micellar mobile phase of 0.02M sodium dodecyl sulfate at pH 7. Acetaminophen is eluted in less than 5 min with no interference of the protein band. The use of electrochemical and UV detection is compared. Linearities (r > 0.9...

Many digital forensic tools used by investigators were not originally designed for forensic applications. Even in the case of tools created with the forensic process in mind, there is the issue of assuring their reliability and dependability. Given the nature of investigations and the fact that the data collected and analyzed by the tools must be presented as evidence, it is important that digi...

*To whom all correspondence should be addressed. otal organic carbon (TOC) analysis is a fast and effective analytical technique for cleaning validation in pharmaceutical manufacturing. This nonspecific method can be used to test for residues of previously manufactured products, cleaning detergents, chemicals, solvents, by-products, degradants, and microbial contaminants. However, many factors ...

Clinicians often base their predictions of walking and arm recovery on multiple predictors. Multivariate prediction models may assist clinicians to make accurate predictions. Several reviews have been published on the prediction of motor recovery after stroke, but none have critically appraised development and validation studies of models for predicting walking and arm recovery. In this review,...

The ruminant provides a powerful model for understanding the temporal dynamics of gastrointestinal microbial communities. Diet-induced milk fat depression (MFD) in the dairy cow is caused by rumen-derived bioactive fatty acids, and is commonly attributed to the changes in the microbial population. The aim of the present study was to determine the changes occurring in nine ruminal bacterial taxa...

the main idea of this paper is to study the dependence between the probability of default and the recovery rate on credit portfolio and to seek empirically this relationship. we examine the dependence between pd and rr by theoretical approach. for the empirically methodology, we use the bootstrapped quantile regression and the simultaneous quantile regression. these methods allow to determinate...

A bioanalytical HPLC method with UV detection for the determination of the antiepileptic drug valproic acid in human saliva has been developed and validated. Saliva represents an alternative matrix for therapeutic monitoring of antiepileptic drugs due to the increasing interest in free drug concentration. The proposed method involved solid-phase extraction for sample preparation and yielded ver...