Residuals are minimized in a correlated dataset by selecting smoothing parameter with optimum performance the spline. The selection methods utilized this study include Generalized Maximum Likelihood (GML), Cross-Validation (GCV), Unbiased Risk (UBR), and Proposed Smoothing Method (PSM). aim of is to compare ability four for autocorrelation structure error term. To achieve purpose, Monte-Carlo s...

patients and methods in this study, 87 specimens from iranian patients were amplified using nested pcr amplification of the ul97 gene. sequence analyses of products were performed for identifying the mutated codons. results the present study show that the most frequent gcv-resistant mutations occurred in codons a594v (26.43%), h520q (18.39%), and m460v (13.79%), consequently occurring at a low ...

Angka kematian maternal menjadi salah satu indikator yang dapat menggambarkan kesejahteraan masyarakat di suatu negara. Pada tahun 2019, Provinsi Jawa Barat tercatat jumlah ibu sebanyak 684 kasus atau 74,19 per 100.000 kelahiran hidup. Salah upaya untuk menurunkan angka dilakukan dengan memodelkan terhadap faktor mempengaruhinya sehingga nilai diestimasi. penelitian ini, diestimasi parameter mo...

We discuss a flexible method for modeling survival data using penalized smoothing splines when the values of covariates change for the duration of the study. The Cox proportional hazards model has been widely used for the analysis of treatment and prognostic effects with censored survival data. However, a number of theoretical problems with respect to the baseline survival function remain unsol...

It has been demonstrated that catheter ablation may be a reliable technique for curing ventricular arrhythmias originating from the great cardiac vein (GCV), and there are some challenges and risks with this therapeutic method. Although some reports described successful catheter ablation of ventricular tachycardias originating from the GCV, premature ventricular contractions (PVCs) with left bu...

It is uncertain whether monitoring plasma ganciclovir (GCV) levels is useful in predicting cytomegalovirus (CMV) DNAemia clearance in preemptively treated allogeneic stem cell transplant recipients. In this observational study, including 13 episodes of CMV DNAemia treated with intravenous (i.v.) GCV or oral valganciclovir, we showed that monitoring trough plasma GCV levels does not reliably pre...

In this paper‎, two inverse problems of determining an unknown source term in a parabolic‎ equation are considered‎. ‎First‎, ‎the unknown source term is ‎estimated in the form of a combination of Chebyshev functions‎. ‎Then‎, ‎a numerical algorithm based on Chebyshev polynomials is presented for obtaining the solution of the problem‎. ‎For solving the problem‎, ‎the operational matrices of int...

The bystander effect is an intriguing phenomenon by which adjacent cells become sensitized to drug treatment during gene therapy with herpes simplex virus thymidine kinase/ganciclovir (HSV-tk/GCV). This effect is reported to be mediated by gap junctional intercellular communication (GJIC), and therefore, we postulated that upregulation of genes that facilitate GJIC may enhance the HSV-tk/GCV by...

The combination of Endostatin (ES) and Herpes Simplex Virus thymidine kinase (HSV-TK) gene therapy is known to have antitumor activity in bladder cancer. The potential effect of ES and TK therapy in glioma has not yet been investigated. In this study, pTK-internal ribosome entry site (IRES), pIRES-ES, and pTK-IRES-ES plasmids were constructed; pIRES empty vector served as the negative control. ...

Treatment of solid-organ transplant (SOT) patients with ganciclovir (GCV)-valganciclovir (VGCV) according to the manufacturer's recommendations may result in over- or underexposure. Bayesian prediction based on a population pharmacokinetics model may optimize GCV-VGCV dosing, achieving the area under the curve (AUC) therapeutic target. We conducted a two-arm, randomized, open-label, 40% superio...