We propose testing for business cycle first-moment asymmetries in Markov-switching autoregressive (MS-AR) models. We derive the parametric restrictions on MS-AR models that rule out types of asymmetries such as deepness, steepness, and sharpness, and set out a testing procedure based on Wald statistics which have standard asymptotics. For a two-regime model, such as that popularised by Hamilton...

a quantitative analysis method for fudosteine in human serum by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (hplc-esi/ms/ms) was established, which shows high sensitivity and selectivity. the mobile phase composition was 75% 20 mm acetic acid and 25% acetonitril, which was pumped at a flow rate of 0.40 ml/min. the overall chromatographic run time was ...

Purpose. To report a case of unilateral optic neuritis following Measles-Mumps-Rubella (MMR) vaccination. Methods. A 30-year-old female developed unilateral optic neuritis five days after a Measles-Mumps-Rubella (MMR) booster vaccination. The patient displayed unilateral involvement, with severe visual loss. However, visual acuity improved significantly after four days of intravenous steroid th...

1818. Immunogenicity of Inactivated Varicella Zoster Vaccine (ZVIN) in Autologous Hematopoietic Stem Cell Transplant (auto-HSCT) Recipients Michael Boeckh, MD, FIDSA; Ann Arvin, MD, FIDSA, FPIDS; Kathleen Mullane, DO, FIDSA; Drew J. Winston, MD; Janice (Wes) Brown, MD; Steven Pergam, MD, MPH, FIDSA; Kimberly Hurtado, BS; Lei Pang, PhD; Ingi Lee, MD, MSCE; Zoran Popmihajlov, MD, MS and on behalf...

It should be noted that Ms Dorey’s claim that “Dr Wakefieldʼs study was only the first of many to indicate a very strong and, in some cases clinically verifiable connection between vaccination and the development of ASDs [autism spectrum disorders]” is incorrect; the Wakefield paper itself does not come to that conclusion. The discussion of the Wakefield paper clearly states “We did not prove a...

Introduction: The world faced serious health and socioeconomic issues with the advent of COVID-19. Along handwashing, social distancing, wearing masks, vaccination was considered by medical authorities as a key way to curb spread virus. One measures that have been proposed increase vaccinations is mandatory policy. purpose this study compare determinants voluntary among students at Albanian Uni...

Coxiella burnetii is a Gram-negative obligate intracellular pathogen and the causative agent of Q fever in humans. Q fever causes acute flu-like symptoms and may develop into a chronic disease leading to endocarditis. Its potential as a bioweapon has led to its classification as a category B select agent. An effective inactivated whole-cell vaccine (WCV) currently exists but causes severe granu...

Persistent infection with high-risk human papilloma viruses (HPV) is the worldwide cause of many cancers, including cervical, anal, vulval, vaginal, penile, and oropharyngeal. Since T cells naturally eliminate the majority of chronic HPV infections by recognizing epitopes displayed on virally altered epithelium, we exploited Poisson detection mass spectrometry (MS(3)) to identify those epitopes...

A proteomic approach was used to investigate the dynamic cellular host cell response induced by influenza virus infection in two different vaccine production cell lines, MDCK and Vero. For identification of proteins possibly involved in global host cell response mechanisms and virus-host cell interactions in these producer cell lines, quantitative 2-D DIGE and nanoHPLC-nanoESI-MS/MS analysis we...