objective: it is well known that diabetes is one of the main health challenges. according to the evidence presented in recent years by investigators, serum uric acid has emerged as a possible risk factor for diabetes mellitus. the aim of the present study was to compare the mean serum uric acid and the antioxidant activity of glutathione levels in patients with diabetes and the control group. m...

this paper describes the development, electrochemical characterization and utilization of novel modified molybdenum (vi) complex-carbon nanotube paste electrode for the electrocatalytic determination of ascorbic acid (aa). the electrochemical profile of the proposed modified electrode was analyzed by cyclic voltammetry (cv) that showed a shift of the oxidation peak potential of aa about 235 mv ...

1. The demonstration of an inheritable anomaly of erythrocyte oxalate transport in 'primary' calcium nephrolithiasis suggested that this disease might be a generalized metabolic disorder characterized by a defect in cellular anion transport. 2. To determine whether this anomaly is restricted to oxalate alone, we studied erythrocyte transmembrane urate self-exchange in calcium-oxalate renal ston...

1. Eight recurrent renal stone-forming patients were housed in a metabolic ward and fed on a low (LPD) and a high (HPD) animal protein diet, which were isoenergetic. Metabolic studies were made after 2 weeks on each diet. 2. There was a 90% increase in urinary urate on HPD compared with LPD, whereas serum urate did not change consistently. 3. The urinary acid excretion increased by 200%, includ...

Two new potential pharmacologic therapies for recurrent stone disease are described. The role of hyperuricosuria in promoting calcium stones is controversial with only some but not all epidemiologic studies demonstrating associations between increasing urinary uric acid excretion and calcium stone disease. The relationship is supported by the ability of uric acid to "salt out" (or reduce the so...

The formation of various types of kidney stones is strongly influenced by urinary pH. An alkaline pH favors the crystallization of calcium- and phosphate-containing stones, whereas and acidic urine pH promotes uric acid or cystine stones. The activity of many transport processes involved in calcium, citrate and phosphate handling are sensitive to changes in systemic or local pH as shown for sev...

During the last few years, there has been relevant progress in both understanding and managing urolithiasis. Our knowledge of stone formation has changed; although the importance of urine biochemistry was questioned by several investigators years ago, the decisive role of cellular processes (induced by oxidative stress) and the renal papilla has only recently been generally accepted as the most...

PURPOSE Recent studies have suggested that renal phosphate leakage and the associated phosphaturia are significant underlying causes of calcium urolithiasis. The aims of this study were to assess whether phosphaturia relates to urinary metabolic abnormalities and recurrent stone formation. MATERIALS AND METHODS A database of patient histories and urine chemistries was analyzed for 1,068 conse...

to study the changes of serum uric acid level which is influenced by various factors including nutrition, race, socio-economic conditions age, sex, obesity and hyper lipidemia, a wide variety of survey appeared to be performed. for this study in six large provinces of iran out of 12,524 apparently healthy individuals a total of 2,744 persons of both sexes (1,439 females, 1,305 males) were selec...