نتایج جستجو برای: uric acid

تعداد نتایج: 747523  

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2009
Andrew D Rule Brooke L Fridley Steven C Hunt Yan Asmann Eric Boerwinkle James S Pankow Thomas H Mosley Stephen T Turner

BACKGROUND Uric acid is heritable and associated with hypertension and insulin resistance. We sought to identify genomic regions influencing serum uric acid in families in which two or more siblings had hypertension. METHODS Uric acid levels and microsatellite markers were assayed in the Genetic Epidemiology Network of Arteriopathy (GENOA) cohort (1075 whites and 1333 blacks) and the Hyperten...

Journal: :Noro psikiyatri arsivi 2014
Bülent Kadri Gültekin Sermin Kesebir Sevgi Gül Kabak Ferzan Fikret Ergün Elif Tatlidil Yaylaci

INTRODUCTION Purinergic system dysfunction has been shown both in patients with bipolar disorder (BD) and those with schizophrenia. The aim of this study was to evaluate whether uric acid levels in male BD patients with manic episode and schizophrenia patients with psychotic relapse differ from healthy male subjects. Secondly to assess whether uric acid levels in both patient groups correlate w...

Journal: :Yao xue xue bao = Acta pharmaceutica Sinica 2010
Qing-hua Hu Xian Zhang Yu Wang Ling-dong Kong

The effects of mangiferin on uric acid excretion, kidney function and related renal transporters were investigated in hyperuricemic mice induced by potassium oxonate. Mice were divided into normal control group, and 5 hyperuricemic groups with model control, 50, 100, and 200 mg x kg(-1) mangiferin, and 5 mg x kg(-1) allopurinol. Mice were administered by gavage once daily with 250 mg x kg(-1) p...

2015
Rafał Donderski Ilona Miśkowiec-Wiśniewska Marek Kretowicz Magdalena Grajewska Jacek Manitius Anna Kamińska Roman Junik Joanna Siódmiak Anna Stefańska Grażyna Odrowąż-Sypniewska Agnieszka Pluta Miguel Lanaspa Richard J Johnson

BACKGROUND Fructose acutely raises serum uric acid in normal subjects, but the effect in subjects with metabolic syndrome or subjects with chronic kidney disease is unknown. The aim of the study was to evaluate changes in serum uric acid during the fructose tolerance test in patients with chronic kidney disease, metabolic syndrome with comparison to healthy controls. METHODS Studies were perf...

2015
Christin Giordano Olga Karasik Kelli King-Morris Abdo Asmar

Uric acid has been implicated in the pathophysiology of renal disease; however renal clearance makes a causal relationship difficult to prove. We examine the current literature to support a potential role of uric acid in the development of kidney disease and to determine the potential to use uric acid as a marker for future renal decline. After review, we conclude that uric acid is definitively...

Journal: :American journal of physiology. Renal physiology 2007
Ho Jae Han Min Jin Lim Yun Jung Lee Jang Hern Lee Il Suk Yang Mary Taub

The accumulation of uric acid, an end-product of purine metabolism, is responsible for the many deleterious effects observed in gouty arthritis, including renal injury. Here, we present evidence that under conditions of hyperuricemia (>10(-4) M uric acid) [(3)H]thymidine incorporation into primary renal proximal tubule cells (PTCs) is inhibited, and we delineate the signaling pathways involved....

2013
Tom M Palmer Børge G Nordestgaard Marianne Benn Anne Tybjærg-Hansen George Davey Smith Debbie A Lawlor Nicholas J Timpson

OBJECTIVES To assess the associations between both uric acid levels and hyperuricaemia, with ischaemic heart disease and blood pressure, and to explore the potentially confounding role of body mass index. DESIGN Mendelian randomisation analysis, using variation at specific genes (SLC2A9 (rs7442295) as an instrument for uric acid; and FTO (rs9939609), MC4R (rs17782313), and TMEM18 (rs6548238) ...

2013
I. Russel Lee Liting Yang Gaseene Sebetso Rebecca Allen Thi H. N. Doan Ross Blundell Edmund Y. L. Lui Carl A. Morrow James A. Fraser

Degradation of purines to uric acid is generally conserved among organisms, however, the end product of uric acid degradation varies from species to species depending on the presence of active catabolic enzymes. In humans, most higher primates and birds, the urate oxidase gene is non-functional and hence uric acid is not further broken down. Uric acid in human blood plasma serves as an antioxid...

Journal: :Internal medicine 2010
Daijiro Uetake Iwao Ohno Kimiyoshi Ichida Yuichiro Yamaguchi Hajime Saikawa Hitoshi Endou Tatsuo Hosoya

OBJECTIVE To examine the effects of fenofibrate, an antilipotropic drug, on uric acid metabolism in healthy male subjects and on urate transporter 1 (URAT1). METHODS Fenofibrate was administered to nine male volunteers at a dose of 300 mg (corresponding to 200 mg of micronized fenofibrate), and the metabolic parameters of uric acid were investigated for more than 12 hours. In addition, the ef...

2005
Virginia M. Weaver Bernard G. Jaar Brian S. Schwartz Andrew C. Todd Kyu-Dong Ahn Sung-Soo Lee Jiayu Wen Patrick J. Parsons Byung-Kook Lee

Recent research suggests that both uric acid and lead may be nephrotoxic at lower levels than previously recognized. We analyzed data from 803 current and former lead workers to determine whether lead biomarkers were associated with uric acid and whether previously reported associations between lead dose and renal outcomes were altered after adjustment for uric acid. Outcomes included uric acid...

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