Matthew T. Roe, MD; Robert A. Harrington, MD; Danielle M. Prosper, MS; Karen S. Pieper, MS; Deepak L. Bhatt, MD; A. Michael Lincoff, MD; Maarten L. Simoons, MD; Martijn Akkerhuis, MD; E. Magnus Ohman, MD; Michael M. Kitt, MD; Alec Vahanian, MD; Witold Ruzyllo, MD; Karl Karsch, MD; Robert M. Califf, MD; Eric J. Topol, MD; for the Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppre...

© R A D C L I F F E C A R D I O L O G Y 2 0 1 5 Introduction Ischaemic heart disease, a major public health issue, is responsible for one in every six deaths and an estimated 1,065,000 will have an acute coronary syndrome (ACS) annually. ACS is an umbrella term that comprises unstable angina, non-ST segment elevation myocardial infarction (NSTEMI) and ST-segment elevation myocardial infarction ...

BACKGROUND Lactococcus lactis is widely used as a dairy starter and has been extensively studied. Based on the acquired knowledge on its physiology and metabolism, new applications have been envisaged and there is an increasing interest of using L. lactis as a cell factory. Plasmids constitute the main toolbox for L. lactis genetic engineering and most rely on antibiotic resistant markers for p...

Perelman [Pe02] has discovered a remarkable variational structure for the Ricci flow: it can be viewed as the gradient flow of the entropy functional λ. There are also two monotonicity formulas of shrinking or localizing type: the shrinking entropy ν, and the reduced volume. Either of these can be seen as the analogue of Huisken’s monotonicity formula for mean curvature flow [Hu90]. In various ...

AIMS The endothelium plays a role in regulating vascular tone. Acute and dynamic changes in low-flow-mediated constriction (L-FMC) and how it changes with regard to traditional flow-mediated dilatation (FMD) have not been described. We aimed to investigate the changes in brachial artery L-FMC following percutaneous coronary intervention (PCI) and during recovery from non-ST-segment elevation my...

L-forms have been shown to occur among many species of bacteria and are suspected to be involved in persistent infections. Since their discovery in 1935, numerous studies characterizing L-form morphology, growth, and pathogenic potential have been conducted. However, the molecular mechanisms underlying the formation and survival of L-forms remain unknown. Using unstable L-form colonies of Esche...

Background: Unstable angina and myocardial infarction are developed due to atherosclerosis of coronary arteries. At present, cholestrol, triglyceride, and lipoproteins are the most common risk factors of death. The purpose of this study was to assess the serum levels of LP (a), LDL-C, VLDL-C, HDL-C in cases of unstable angina and myocardial infarction.Methods: This study was conducted to compar...