Male infertility represents one of the clearest examples of complex phenotype with substantial genetic basis. It is indeed well established that genetic causes account for 10-15% of infertility cases, including chromosomal abnormalities and single-gene mutations. However, a large proportion of infertile males does not receive a clear diagnosis and thus they are reported as idiopathic or unexpla...

Abstract Study question: What is the optimal work-up to establish diagnosis of unexplained infertility, based on best available evidence in literature? Summary answer: The ESHRE Guideline Unexplained Infertility provides 35 recommendations infertility. known already? infertility made when no abnormalities female and/or male reproductive systems are clearly identified. UI inevitably a by exclusi...

Complete deletions in the AZF (a, b, and c) sub-regions of the Y-chromosome have been shown to contribute to unexplained male infertility. However, the role of partial AZFc deletions in male infertility remains to be verified. Three types of partial AZFc deletions have been identified. They are gr/gr, b1/b3, and b2/b3 deletions. A recent meta-analysis showed that ethnic and geographical factors...

Background Recurrent pregnancy loss (RPL) is defined as the loss of at least three pregnancies in the first trimester. Although the most common cause is embryo aneuploidy, and despite female checkup and couple karyotyping, in about 50% of cases RPL remain unexplained. Male implication has little been investigated and results are discordant. In this context, we conducted a multi-center prospecti...

OBJECTIVES A large prospective clinical trial was conducted to compare the efficacy of single dose uFSH and clomiphene citrate combination with clomiphene citrate alone for ovulation induction to improve the pregnancy rate. MATERIALS AND METHODS The study was a randomized, prospective clinical trial. Totally, 1527 infertile women (4381 cycles) with polycystic ovarian syndrome (PCOS) (n=911/25...

Background: Epidemiological study of infertility might let the related policy makers to make accurate decisions regarding the potential users’ requirements for infertility workup or management. The objective of this study was to find the incidence and etiologic factors for infertility in Iranian population. Methods: an internet based search through PubMed, Google Scholar, Iran Medex, magiran an...

Infertility is a relatively common health condition, affecting nearly 7% of all couples. Clinically, it is a highly heterogeneous pathology with a complex etiology that includes environmental and genetic factors. It has been estimated that nearly 50% of infertility cases are due to genetic defects. Hundreds of studies with animal knockout models convincingly showed infertility to be caused by g...

The prevalence of male infertility appraised 10-15% in worldwide. Male infertility is frequently coupled to deficient in sperm development and production (1). Of note, in principle of the number of sperm cells in seminal fluid, has been categorised in azoospermia, severe oligozoospermia and mild oligozoospermia. In azoospermia condition, a sperm cell counts approximately ≤5×10 cells/mL, and in ...

OBJECTIVE To investigate the value of stimulated intrauterine insemination (IUI) in women with unilateral tubal occlusion. METHODS Superovulation and IUI was performed during 2003-2010 and the medical records were reviewed retrospectively. Thirty-seven infertile women (52 cycles) with unilateral tubal occlusion diagnosed by hysterosalpingography and without other causes of infertility were se...