BACKGROUND Ellipticine and doxorubicin are antineoplastic agents, whose action is based mainly on DNA damage such as intercalation, inhibition of topoisomerase II and formation of covalent DNA adducts. The key target to resolve which of these mechanisms are responsible for ellipticine and doxorubicin anticancer effects is the development of suitable methods for identifying their individual DNA-...

[1] A dual unscented Kalman filter (UKF) was used to assimilate net CO2 exchange (NEE) data measured over a spruce-hemlock forest at the Howland AmeriFlux site in Maine, USA, into a simple physiological model for the purpose of filling gaps in an eddy flux time series. In addition to filling gaps in the measurement record, the UKF approach provides continuous estimates of model parameters and u...

Data assimilation is a valuable tool in the study of any complex system, where measurements are incomplete, uncertain, or both. It enables the user to take advantage of all available information including experimental measurements and short-term model forecasts of a system. Although data assimilation has been used to study other biological systems, the study of the sleep-wake regulatory network...

Stability and control characteristics analysis has long been the important research area of aircraft flight dynamics, which is the critical factor of control system design, performance evaluation and integrated design of aircraft. The linear perturbation equations describing aircraft longitudinal and lateral motion, which are derived from nonlinear dynamic equations based on the small perturbat...

Neuroblastoma is a tumor accounting for approximately 10% of all childhood malignancies and 50% of all childhood cancer-related deaths. MYCN gene copy number variation represents the most important prognostic factor in neuroblastoma. Prognostic significance of MYCN gene expression is more complicated and may depend on other factors such as MYCN gene copy number status. In the present study, we ...

This paper aims to investigate several new nonlinear/non-Gaussian filters in the context of the sequential data assimilation. The unscentedKalman filter (UKF), the ensemble Kalman filter (EnKF), the sampling importance resampling particle filter (SIR-PF) and the unscented particle filter (UPF) are described in the state-space model framework in the Bayesian filtering background. We first evalua...

Measles virus (MV) infects a variety of lymphoid and non-lymphoid peripheral organs. However, in rare cases, the virus can persistently infect cells within the central nervous system. Although some of the factors that allow MV to persist are known, the contribution of host cell-encoded microRNAs (miRNA) have not been described. MiRNAs are a class of noncoding RNAs transcribed from genomes of al...

Satellites provide various services essential to the modern life of human being. For example, satellite images are used for many applications such as reconnaissance, geographic information system, etc. Therefore, design and operation requirements of the satellite system have become more severe, and also the system reliability during the operation is required. Satellite attitude control systems ...

The Extended Kalman Filter (EKF) has become a standard technique used in a number of nonlinear estimation and machine learning applications. These include estimating the state of a nonlinear dynamic system, estimating parameters for nonlinear system identification (e.g., learning the weights of a neural network), and dual estimation (e.g., the ExpectationMaximization (EM) algorithm)where both s...