BACKGROUND Although natriuretic peptides are considered cardioprotective, clinical heart failure trials with recombinant brain natriuretic peptide (nesiritide) failed to prove it. Unsuspected proadrenergic effects might oppose the anticipated benefits of natriuretic peptides. METHODS AND RESULTS We investigated whether natriuretic peptides induce catecholamine release in isolated hearts, symp...

Many studies have described the role of B-type natriuretic peptide or its amino-terminal byproduct (NT-pro-B-type natriuretic peptide) in clinical practice, including several published or ongoing randomized clinical trials. However, the debate over natriuretic peptide testing continues, mostly related to the appropriateness of testing as decision support for the management of heart failure. The...

Many studies have described the role of B-type natriuretic peptide or its amino-terminal byproduct (NT-pro-B-type natriuretic peptide) in clinical practice, including several published or ongoing randomized clinical trials. However, the debate over natriuretic peptide testing continues, mostly related to the appropriateness of testing as decision support for the management of heart failure. The...

BACKGROUND Dendroaspis natriuretic peptide (DNP), recently isolated from the venom of the green Mamba snake Dendroaspis angusticeps, is a 38 amino acid peptide containing a 17 amino acid disulfide ring structure similar to that of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). DNP-like immunoreactivity (DNP-LI) was reported to be present...

BACKGROUND Measurement of circulating natriuretic peptides has been shown to play an important role in diagnosis and prognosis in patients with chronic heart failure. Whether serial natriuretic peptide measurements to aid in the titration of therapy can improve heart failure outcomes remains uncertain. We performed a quantitative meta-analysis of available randomized controlled trials to determ...

We thank Drs Chang and Hancox for their interest in our work on natriuretic peptides in community-acquired pneumonia. 1 – 4 The current report 1 extends our previous observations and tries to highlight fi ndings that (1) apply to the whole family of natriuretic peptides in general and (2) provide a direct comparison of the clinical potential of all three commercially available natri uretic pep...

Osteocrin (Ostn) is a recently discovered secreted protein produced by cells of the osteoblast lineage that shows a well conserved homology with members of the natriuretic peptide (NP) family. We hypothesized that Ostn could interact with the NP receptors, thereby modulating NP actions on the skeleton. Ostn binds specifically and saturably to the NP peptide receptor-C (NPR-C) receptor with a Kd...