Cilnidipine, a dual calcium channel antagonist, is assumed to regulate hypertension via Nand L-type calcium channel. The N-type calcium channel is associated with sympathetic nerve activation. This effect may improve the glomerular hemodynamics in the injured nephron, and may mitigate the progression of renal injury. To clarify the effect of cilnidipine in instances of already existing decrease...

Most of the whole-cell calcium current of frog sympathetic neurons is an N-type current, blocked by omega-conotoxin GVIA (omegaCGVIA). Thus, these cells should be an excellent system to study the properties of single N-type channels. However, a channel that is active near -10 mV in isotonic Ba2+, originally identified as "N-type," corresponds more closely to a omegaCGVIA-resistant component of ...

Natriuretic peptides are cyclized peptides produced by cardiovascular and neural tissues. These peptides inhibit various secretory responses such as the release of renin, aldosterone and autonomic neurotransmitters. This report tests the hypothesis that atrial natriuretic peptide reduces dopamine efflux from an adrenergic cell line, rat pheochromocytoma cells, by suppressing intracellular calci...

Effects of haloperidol on L-type CaV1.2 channel were studied. Calcium current was measured in whole cell patch-clamp using calcium as a charge carrier. Inhibition by haloperidol was investigated in CaV1.2 channel natively expressed in rat cardiac myocytes and recombinant cardiac (CaV1.2a) and vascular (CaV1.2b) splice variants of the channel expressed in HEK 293 cells. Haloperidol inhibited L-t...

PURPOSE To test the hypothesis that intraretinal calcium channels participate in retinal morbidity in a variable oxygen (VO) model of retinopathy of prematurity. METHODS In control and VO Long Evans (LE) rats, either untreated or treated with voltage- or ligand-gated calcium channel antagonists, we measured retinal neovascular (NV) incidence and severity (adenosine diphosphatase staining), an...