AIMS left ventricular (LV) twist is the result of clockwise rotation of the base and counterclockwise rotation of the apex. The aims of this study were to investigate the feasibility of the three-dimensional speckle-tracking echocardiography (3DSTE) to assess LV twist values and compare the data measured by two-dimensional speckle-tracking echocardiography (2DSTE) in a group of healthy voluntee...

Epithelial-to-mesenchymal transition (EMT) facilitates tumor metastasis. Twist is a basic helix-loop-helix protein that modulates many target genes through E-box-responsive elements. There are two twist-like proteins, Twist-1 and Twist-2, sharing high structural homology in mammals. Twist-1 was found to be a key factor in the promotion of metastasis of cancer cells, and is known to induce EMT. ...

PURPOSE Hepatocellular carcinoma (HCC) is a rapidly growing tumor associated with a high propensity for vascular invasion and metastasis. Epithelial-mesenchymal transition (EMT) is a key event in the tumor invasion process. Recently, Twist has been identified to play an important role in EMT-mediated metastasis through the regulation of E-cadherin expression. However, the actual role of Twist i...

Aberrant epidermal growth factor receptor (EGFR) signaling is a major cause of tumor progression and metastasis; the underlying mechanisms, however, are not well understood. In particular, it remains elusive whether deregulated EGFR pathway is involved in epithelial-mesenchymal transition (EMT), an early event that occurs during metastasis of cancers of an epithelial origin. Here, we show that ...

Deformation of the material during cyclic expansion extrusion (CEE) is investigated using upper-bound theorem. The analytical approximation of forming loads agrees very well with the FEM results for different amounts of chamber diameter, friction factor and also for lower die angles. However, the difference between analytical and numerical solution increases at higher die angles which are expla...

Loss of estrogen receptor α (ERα) expression and gain of TWIST (TWIST1) expression in breast tumors correlate with increased disease recurrence and metastasis and poor disease-free survival. However, the molecular and functional regulatory relationship between TWIST and ERα are unclear. In this study, we found TWIST was associated with a chromatin region in intron 7 of the human ESR1 gene codin...