Members of the Twist-family of bHLH proteins play a pivotal role in a number of essential developmental programs. Twist-family bHLH proteins function by dimerizing with other bHLH members and binding to cis- regulatory elements, called E-boxes. While Twist-family members may simply exhibit a preference in terms of high-affinity binding partners, a complex, multilevel cascade of regulation creat...

The buckling torque may be much less than the yield torque in very thin rectangular tubes under torsion. In this paper, simple closed-form formulae are presented for buckling analysis of long hollow rectangular tubes under torsion. By the presented formulae, one can obtain the critical torque or the critical angle of twist of the tube in terms of its geometrical parameters and material constant...

Recently, TWIST, a basic helix-loop-helix transcription factor, is suggested to be an oncogene because of its over-expression in many types of human cancer and its positive role in promoting cell survival. The aim of this study was to investigate the role of TWIST on the growth of human epithelial cells. Using two immortalized human prostate epithelial cell lines, we demonstrated that inactivat...

PURPOSE To evaluate the diagnostic value of time resolved magnetic resonance angiography with interleaved stochastic trajectory (TWIST) using Gadobutrol for preoperative evaluation of lower extremity tumors. MATERIALS AND METHODS This prospective study was approved by the local Institutional Review Board. 50 consecutive patients (31 men, 19 women, age range 18-80 years, average age 42.7 years...

We discuss the relations between the twist 2 and twist 3 contributions to polarized deep-inelastic scattering structure functions both for neutral and charged current interactions which are predicted by the operator product expansion in lowest order in QCD. INTRODUCTION In the case of polarized deep inelastic scattering the cross sections depend on (up to) three unpolarized Fi(x,Q 2)3i=1 and fi...

A method for achieving an arbitrary lift distribution with an arbitrary planform is presented. This is accomplished through optimizing aerodynamic twist for a given number of either known airfoils or airfoils to be designed. The spanwise locations of these airfoils are optimized to get as close to the desired lift distribution as possible. Airfoils are linearly interpolated between these points...

At the 1988 Seoul Olympic Games, four double somersaults dismounts with one twist and four double somersault dismounts with two twists were filmed using two 16 mm cameras during the men’s horizontal bar competition. Contributions to tilt angles reached at the mid-twist position, determined using computer simulations based on modifications of the data obtained from film, were used as measures of...

In Drosophila, a coordinate interplay between the Rel transcription factor Dorsal and the basic Helix-Loop-Helix transcription factor Twist initiates mesoderm formation by activating the zygotic expression of mesoderm-determining genes. Here, we show that TBP-associated-factors (TAF(II)s) within the basal transcription factor TFIID mediate transcriptional activation by Dorsal and Twist. Dorsal ...

Metastasis is a multistep process during which cancer cells disseminate from the site of primary tumors and establish secondary tumors in distant organs. In a search for key regulators of metastasis in a murine breast tumor model, we have found that the transcription factor Twist, a master regulator of embryonic morphogenesis, plays an essential role in metastasis. Suppression of Twist expressi...

To understand the role of twist during mammalian development, we generated twist-null mice. twist-null embryos died at embryonic day 11.5. Their most prominent phenotype was a failure of the cranial neural folds to fuse. Mutant embryos also had defects in head mesenchyme, somites, and limb buds. Chimera analysis suggested that head mesenchyme was required for cranial neural tube closure and tha...