Dr. Robert Kerbel and his lab at Sunnybrook Research Institute have found that antiangiogenic drugs, shown to slow tumour growth in some cancer patients, might also accelerate metastasis in certain preclinical circumstances. The journal Cancer Cell published the results on March 3; here, Dr. John Ebos, a postdoctoral fellow in the Kerbel lab and lead author of the study, discusses what the find...

Ramucirumab is an antiangiogenesis agent targeting the vascular endothelial growth factor receptor-2 (VEGFR-2), approved to treat advanced gastric and colon cancer. In clinical trials, it was shown to cause a small increase in arterial thromboembolism compared to placebo, including cerebral and myocardial ischemia, which was not statistically significant. Detailed case reports are lacking and w...

Choroidal metastasis from lung cancer is uncommon. We report a case of choroidal metastasis as an inaugural manifestation of lung adenocarcinoma, successfully treated by docetaxel, cisplatinum, and intravenous bevacizumab as an antiangiogenesis therapy. A complete remission was obtained after 4 cycles and maintained after six cycles. This case report demonstrates the importance of the systemic ...

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant diseases because its non-symptomatic tumorigenesis. We previous found heat shock factor 1 (HSF1) was critical for PDAC progression and aim this study to clarified mechanisms on early activation HSF1 role in pancreatic cancer Methods The expression location human or mice tissues were examined by immunohistoc...