OBJECT Unlike whole-brain radiation therapy, Gamma Knife surgery (GKS) is delivered in a single session for the treatment of brain metastases. The extent to which GKS can facilitate early tumor control was the focus of this study. METHODS The authors reviewed 134 metastatic lesions in 82 patients treated with GKS at the University of Virginia who underwent follow-up MR imaging within 30 days ...

In this paper, analysis of brain tumor growth using a dimensionality reduction method (DRM), i.e., multidimensional scaling (MDS) is presented. The data of one patient’s complete MRI records scanned during his visits in the past two years are used for the analysis. There are ten MRI series, including DTI, for each visit. After registering all series to the corresponding DTI scan at the first vi...

For thymoma, multidisciplinary antitumor strategy is composed of surgery, chemotherapy, and radiotherapy. Meanwhile, ~20% to 25% of patients with thymoma have myasthenia gravis and plasmapheresis is recommended for thymoma-associated myasthenia gravis.We report a case that a 40-year-old woman with thymoma experiencing tumor relapse after surgery showed significant response to plasmapheresis.Thi...

Laminin, a glycoprotein of basement membranes, binds to the surface of cultured human pancreatic carcinoma cells (PANC-1). The binding is saturable, with a high proportion of specific binding, as determined by competition of labeled ligand with 80-fold excess unlabeled ligand. Pretreatment of the carcinoma cells with butyrate markedly reduces the amount of specific laminin binding. The butyrate...

Castration of rats transplanted with the androgen-sensitive Dunning R3327-PAP prostituÃ--tumor results initially in a reduction of tumor growth, but after some time, some of the tumors start to grow again. The relapsed, androgen-insensitive PAP tumor shows a dedifferentiated mor phology. In the present study, we examined whether this androgen-independent tumor regrowth was due to an increased c...