Inhibition of matrix-metalloproteinases (MMPs) by tissue inhibitors of metalloproteinases (TIMPs) has been shown in vivo to decrease metastasis and tumor-associated angiogenesis. Our laboratory is interested in understanding the role of these proteins at the pericellular microenvironment of tumor and endothelial cells. Secretion of MMPs by tumor cells enables the migration, invasion and metasta...

conclusions nbi cystoscopy improved the detection rate. although false positives were more common with nbi, this was not statistically significant. nbi found additional aggressive tumors, which underscores the impact of detection in eortc recurrence risk scoring. results fifty patients, aged 63.86 ± 10.05 years, were enrolled. the overall detection rate was 98.9% for nbi vs. 89.4% for wli (p = ...

bladder cancer is the most frequent genitourinary malignancy in iran. environmental and genetic factors are the two factors linked with bladder cancer expansion. the aim of this study was to investigate the role of pten gene and environmental risk factors on the progression and prognosis of bladder cancer.we evaluated 55 tumor specimens and 66 bladder mucosa samples of non-cancerous patients be...

Abstract T cell exhaustion is a major contributor to tumor immune invasion. The durability of an anti-tumor response in part determined by the persistence exhausted CD8 progenitors (Tpex) that reconstitute effector pool. While it has been reported Tpex are able survive without antigen, role TCR engagement regulating self-renewal during progression remains be fully explored. Here, we used Lewis ...

The development of tumors requires an initiator event, usually exposure to DNA damaging agents that cause genetic alterations such as gene mutations or chromosomal abnormalities, leading deregulated cell proliferation. Although the mere stochastic accumulation further may tumor progression, it is now clear inflammatory microenvironment has a major tumor-promoting influence on initiated cells, i...

Urinary-tract-related tumors are prone to simultaneous or heterogeneous multiple tumor development within the primary organ. Urologic have a very high risk of recurrence in long and short term. This may be related disruption homeostasis on genetic level, such as induction mutations due exposure various carcinogenic factors cancer suppressor gene functions. It is essential detect progression sig...