Introduction: High-energy beams of protons offer significant advantages for the treatment of deepseated local tumors. Their physical depth-dose distribution in tissue is characterized by a small entrance dose and a distinct maximum -Bragg peak- near the end of range with a sharp fall-off at the distal edge. Alongside its advantages there are some point that they need to meticul...

Immune cells in the tumor microenvironment modulate cancer progression and are attractive therapeutic targets. Macrophages and T cells are key components of the microenvironment, yet their phenotypes and relationships in this ecosystem and to clinical outcomes are ill defined. We used mass cytometry with extensive antibody panels to perform in-depth immune profiling of samples from 73 clear cel...

A 66-year-old Japanese man was referred to our hospital because of suspected duodenal cancer. Upper gastric endoscopy revealed a giant polypoid-type tumor that extended from the duodenum bulb to the pyloric ring. A computed tomography scan revealed a slightly enhanced lobular tumor protruding into the duodenum bulb. Positron emission tomography showed an accumulation of (18)F-fluorodeoxyglucose...

AIM to assess prognostic significance of pathologic features T1 rectal carcinoma in relation regional lymph nodes involvement (N+). MATERIAL AND METHODS : surgical specimens (n = 66) from resection for pT1 were investigated. Following prognosticators evaluated: depth submucosal invasion, grade differentiation, lymphovascular invasion (LVI), tumor budding (Bd), poorly differentiated clusters (PD...

Introduction:  On  the  basis  of  percent  depth  dose  (PDD)  calculation,  the  application  of  dosimetry  in  radiotherapy  has  an  important  role  to  play  in  reducing  the  chance  of  tumor  recurrence. The aim of this study is to introduce a new formula for calculating the centeral axis  percent depth doses of Cobalt-60 beam.   Materials and Methods: In the present study, based on ...

BACKGROUND Irreversible electroporation (IRE) is a novel ablation tool that uses brief high-voltage pulses to treat cancer. The efficacy of the therapy depends upon the distribution of the electric field, which in turn depends upon the configuration of electrodes used. METHODS We sought to optimize the electrode configuration in terms of the distance between electrodes, the depth of electrode...

purpose: to present a case of orbital granular cell tumor, a rare orbital tumor. case report: a 55-year-old woman presented with binocular diplopia and right ocular displacement. the problem had initiated 3 years ago. a firm nontender mass at the region of the right lower lid was visible. orbital ct-scan disclosed a well-defined mass in the inferior right orbit with involvement of the inferior ...

results there was no statistical difference between the 2 groups with respect to the recurrence rate (p > 0.05). although the recurrence interval was longer for the metformin group, this increase was not statistical significant (p > 0.05). furthermore, tumor recurrence had no correlation with sex or the grade of the tumors. conclusions according to our findings, it seems that metformin has no c...

light is never being distributed homogeneously and it forms a gradient over biomass. the unidirectional nature of light gives rise to a vertical gradient of light intensity as a function of depth. the maximum depth of the light zone suitable for phytoplankton photosynthesis is designated as the euphotic depth. this study was designed to test the hypothesis of mixing depth of phytoplankton and i...

Digital holographic optical coherence imaging is a full-frame coherence-gated imaging approach that uses a CCD camera to record and reconstruct digital holograms from living tissue. Recording digital holograms at the optical Fourier plane has advantages for diffuse targets compared with Fresnel off-axis digital holography. A digital hologram captured at the Fourier plane requires only a 2D fast...