نتایج جستجو برای: tubular cell

تعداد نتایج: 1705670  

Journal: :American journal of physiology. Renal physiology 2015
Hee-Seong Jang Babu J Padanilam

Proximal tubular injury and apoptosis are key mediators of the development of kidney fibrosis, a hallmark of chronic kidney disease. However, the molecular mechanism by which tubular apoptotic cell death leads to kidney fibrosis is poorly understood. In the present study, we tested the roles of Bcl-2-associated X (Bax) and Bcl-2 antagonist/killer (Bak), two crucial proteins involved in intrinsi...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 1998
Y Terada S Inoshita O Nakashima M Kuwahara S Sasaki F Marumo

Our understanding of the cell-cycle mechanisms has progressively advanced in the past few years. Cyclins and cyclin-dependent kinases play major roles as positive cell-cycle regulatory proteins and CDK inhibitors; while the Kip family and INK4 family are negative regulatory proteins in mesangial cells and renal tubular cells. An understanding of the cell cycle is essential for the rational desi...

Journal: :The Kaohsiung journal of medical sciences 2011
Turgay Akgül Emre Huri Hatice Yagmurdur Ali Ayyıldız Hüseyin Ustün Cankon Germiyanoğlu

The aim of the present study was to evaluate the effects of phosphodiesterase 5 inhibitors on renal tubular apoptosis and also on expressions of endothelial and inducible nitric oxide synthases (eNOS and iNOS) in the ipsilateral kidney after partial unilateral ureteral obstruction (PUUO) in a rat model. Forty Wistar albino rats were divided into five groups. In Groups 1-4, left experimental PUU...

2017
Dong Yeon Kim Min-Kyung Kang Sin-Hye Park Eun-Jung Lee Yun-Ho Kim Hyeongjoo Oh Yean-Jung Choi Young-Hee Kang

Renal tubulointerstitial fibrosis is an important event in the pathogenesis of diabetic nephropathy. Under pathologic conditions, renal tubular epithelial cells undergo transition characterized by loss of cell-cell adhesion and increased cell migration. This study investigated that eucalyptol inhibited tubular epithelial cell disjunction and tubulointerstitial fibrosis stimulated by glucose. Hu...

Journal: :iranian journal of pathology 2015
smiley annie george suad abdeen

calcifying fibrous tumor (cft) is a rare mesenchymal tumor, affecting children and young adults with a predilection for the soft tissue and the abdominal cavity. cft of the tubular gastrointestinal tract is very rare with less than 20 cases of gastric cfts reported in english literature. this benign hypocellular fibrosclerotic calcifying lesion can resemble other spindle cell tumors particularl...

2010
Maria D. Sanchez-Niño Alberto Benito-Martin Sara Gonçalves Ana B. Sanz Alvaro C. Ucero Maria C. Izquierdo Adrian M. Ramos Sergio Berzal Rafael Selgas Marta Ruiz-Ortega Jesus Egido Alberto Ortiz

Members of the TNF superfamily participate in kidney disease. Tumor necrosis factor (TNF) and Fas ligand regulate renal cell survival and inflammation, and therapeutic targeting improves the outcome of experimental renal injury. TNF-related apoptosis-inducing ligand (TRAIL and its potential decoy receptor osteoprotegerin are the two most upregulated death-related genes in human diabetic nephrop...

2017
Yanjun Long Xin Zhen Fengxin Zhu Zheng Hu Wenjing Lei Shuang Li Yan Zha Jing Nie

Hyperhomocysteinemia (HHcy) has been linked to several clinical manifestations including chronic kidney disease. However, it is not known whether HHcy has a role in the development of acute kidney injury (AKI). In the present study, we reported that HHcy mice developed more severe renal injury after cisplatin injection and ischemia-reperfusion injury shown as more severe renal tubular damage an...

2015
Evangelia Papadimou Marina Morigi Paraskevas Iatropoulos Christodoulos Xinaris Susanna Tomasoni Valentina Benedetti Lorena Longaretti Cinzia Rota Marta Todeschini Paola Rizzo Martino Introna Maria Grazia de Simoni Giuseppe Remuzzi Michael S. Goligorsky Ariela Benigni

The application of cell-based therapies in regenerative medicine is gaining recognition. Here, we show that human bone marrow stromal cells (BMSCs), also known as bone-marrow-derived mesenchymal cells, can be reprogrammed into renal proximal tubular-like epithelial cells using cell-free extracts. Streptolysin-O-permeabilized BMSCs exposed to HK2-cell extracts underwent morphological changes-for...

Journal: :Journal of the American Society of Nephrology : JASN 2004
Takao Masaki Cosimo Stambe Prudence A Hill John Dowling Robert C Atkins David J Nikolic-Paterson

Examined was extracellular-signal regulated kinase (ERK) activation in normal human kidney (n = 2) and a cohort of glomerulopathies by immunohistochemistry staining for the dual-phosphorylated form of ERK (p-ERK). Cell proliferation was determined by expression of the proliferating cell nuclear antigen (PCNA). In normal human kidney, p-ERK was largely restricted to the cytoplasm of cells of the...

2015
Shunsaku Nakagawa Kumiko Nishihara Hitomi Miyata Haruka Shinke Eri Tomita Moto Kajiwara Takeshi Matsubara Noriyuki Iehara Yoshinobu Igarashi Hiroshi Yamada Atsushi Fukatsu Motoko Yanagita Kazuo Matsubara Satohiro Masuda Hideharu Abe

In chronic kidney disease (CKD), progressive nephron loss causes glomerular sclerosis, as well as tubulointerstitial fibrosis and progressive tubular injury. In this study, we aimed to identify molecular changes that reflected the histopathological progression of renal tubulointerstitial fibrosis and tubular cell damage. A discovery set of renal biopsies were obtained from 48 patients with hist...

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