Although tuberculin test is widely used for detection of tuberculous infection among children, there is no clear understanding about its performance and interpretation. This article has been written with the purpose of elucidating the performance and interpretation of standard tuberculin test, based on the experiences gained at the National Tuberculosis Institute, Bangalore and other centres. T...

OBJECTIVE To investigate the influence of BCG vaccination or revaccination on tuberculin skin test reactivity, in order to guide the correct interpretation of this test in a setting of high neonatal BCG vaccination coverage and an increasing BCG revaccination coverage at school age. METHODS We conducted tuberculin skin testing and BCG scar reading in 1 148 children aged 7-14 years old in the ...

THE CONCLUSIONS TO BE DEDUCED FROM THIS BRIEF SERIES OF EXPERIMENTS ARE AS FOLLOWS: 1. The ophthalmo-tuberculin reaction is of some value for diagnosis of tuberculosis in cattle. A characteristic conjunctivitis with fibrinous exudation coming on from six to eight hours, reaching a maximum in from sixteen to twenty-four hours and disappearing in forty-eight hours, is noted in tubercular animals....

During the early phase of bacteriological-immunological work on tuberculosis, many answers to unsolved questions were sought in serological reactions and in antigen-antibody relations, demonstrable either in vitro or in vivo. A product of that time is the work of Pickert and of Lowenstein3 on the so-called "procutins" and "anticutins." They were considered in terms of antibodies specific to tub...

BACKGROUND Bovine tuberculosis, caused by Mycobacterium bovis, afflicts approximately 50 million cattle worldwide and is detected by the tuberculin skin test (TST). While it has long been recognized that purified protein derivative (PPD) tuberculin is composed of a mixture of M. bovis derived protein components, little is known about the quality, relative quantity and identity of the proteins t...

History: This macaque was imported from the Philippines in 1990 to augment the breeding colony at the California Regional Primate Research Center. Four years later she was brought to the attention of the veterinary service because of an equivocal tuberculin reaction and the presence of a skin rash. A follow up skin test using mammalian tuberculin, avian tuberculin and a sterile saline control p...

The precise origin of cells infiltrating tuberculin skin reactions was studied with the technique of immunofluorescence. Thymectomized, irradiated Lewis rats were restored with bone marrow from allogeneic or F(1) donors. They were passively sensitized to tuberculin by a subsequent transfer of Lewis lymph node cells and were given intradermal skin tests with tuberculoprotein. In 24 hr reactions ...

New toxic substances in certain tuberculin, O.T., and B. typhosus culture filtrates are described. These substances are capable of eliciting the hemorrhagic necrosis characteristic of the phenomenon of local skin reactivity provided heterologous bacterial filtrates of high potency are used either for the intradermal or the intravenous injection. The toxic substances apparently have no relations...

OBJECTIVE: To evaluate the role of the tuberculin test in the diagnosis of tuberculosis in children. METHODS: Test diagnosis study; Tuberculin test with PPD Rt 23 (2 UT) was performed in 158 children, distributed in 2 groups: 101 no tuberculous, BCG vaccinated children and 57 tuberculous ones (diagnosis by clinical-radiological and epidemiological features). The interpretation of the tuberculin...

(Received for publication, December 24, 1957) In tuberculous cases of children, the erythrocytes sensitized with tuberculinpolysaccharide were detected by means of the agglutination reaction between the erythrocytes and the immune serum prepared in the following way. Sheep were treated by repeated injection of killed tubercle bacilli, until the serum ob tained from same was able to cause an agg...