AIM 2,3,5,4'-Tetrahydroxy-stilbene-2-O-β-d-glucoside (TSG), a natural stilbene, shows great activities in hepatic lipid regulation, especially for hepatic triglyceride lowering. However, information about its mechanisms on biosynthesis and degradation of triglyceride is still limited. This research pays close attention to clarify the mechanism of TSG on prevention of hepatic lipid accumulation....

BACKGROUND Endothelial cell dysfunction triggered by oxidized low-density lipoprotein (oxLDL) is the main event occurring during the development of atherosclerosis. 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG), an active component of the rhizome extract from Polygonum multiflorum, exhibits significant anti-atherosclerotic activity. However, the protective effects of TSG against oxLDL-i...

Current strategies for Alzheimer’s disease (AD) treatment are mainly symptomatic; development of disease-modifying therapies is urgently needed. Polygonum Multiflorum has been used in Traditional Chinese Medicine for long history in treatment of dementia. Pharmacological studies suggested Polygonum Multiflorum could improve learning and memory abilities in animal models of AD, and inhibit β-amy...

Concurrent trace programs (CTPs) are slices of the concurrent programs that generate the concrete program execution traces, where inter-thread event order specific to the given traces are relaxed. For such CTPs, we introduce transaction sequence graph (TSG) as a model for efficient concurrent data flow analysis. The TSG is a digraph of thread-local control nodes and edges corresponding to trans...

BACKGROUND The efficacy of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) treatment on cognitive decline in individuals with Alzheimer's disease (AD) has not been investigated. Therefore, we systematically reviewed the effect of TSG on cognitive deficits in a rodent model of AD. METHODS We identified eligible studies published from January 1980 to April 2015 by searching seven elect...

Background. Sequential treatments of Chinese medicines for acute exacerbation of chronic obstructive pulmonary disease (AECOPD) risk window (RW) have benefits for preventing reoccurrences of AEs; however, the effects on pulmonary function, pulmonary, and systemic inflammatory biomarkers remain unclear. Methods. Cigarette-smoke/bacterial infections induced rats were randomized into Control, COPD...

The present document has been developed within the 3 rd Generation Partnership Project (3GPP TM) and may be further elaborated for the purposes of 3GPP. The present document has not been subject to any approval process by the 3GPP Organisational Partners and shall not be implemented. This Specification is provided for future development work within 3GPP only. The Organisational Partners accept ...

In this paper, we present the first incremental parser for Tree Substitution Grammar (TSG). A TSG allows arbitrarily large syntactic fragments to be combined into complete trees; we show how constraints (including lexicalization) can be imposed on the shape of the TSG fragments to enable incremental processing. We propose an efficient Earley-based algorithm for incremental TSG parsing and repor...

Tumor suppressor genes (TSGs) are important gatekeepers that protect against somatic evolution of cancer. Losing both alleles of a TSG in a single cell represents a step toward cancer. We study how the kinetics of TSG inactivation depends on the population size of cells and the mutation rates for the first and second hit. We calculate the probability as function of time that at least one cell h...

Link modules are hyaluronan-binding domains found in proteins involved in the assembly of extracellular matrix, cell adhesion, and migration. The solution structure of the Link module from human TSG-6 was determined and found to consist of two alpha helices and two antiparallel beta sheets arranged around a large hydrophobic core. This defines the consensus fold for the Link module superfamily,...