Cyclic tetrapyrroles are among the most potent compounds with activity against transmissible spongiform encephalopathies (TSEs; or prion diseases). Here the effects of differential sulfonation and metal binding to cyclic tetrapyrroles were investigated. Their potencies in inhibiting disease-associated protease-resistant prion protein were compared in several types of TSE-infected cell cultures....

OVER the past four years the editorial board of TSE has worked to identify and address challenges and opportunities in the publication of research contributions in the field of software engineering. As we have reported in prior editorials, TSE has made consistent and substantial progress in reducing the time to review submitted manuscripts and has helped to create the successful, and growing, “...

THE past 12 months have been an eye opening experience for me as editor-in-chief of the IEEE Transactions on Software Engineering (TSE). I have come to understand the enormous professional and community effort involved in the publication of the top journal in the field of software engineering research. Contributions come in many forms and from many people. Many hundreds of authors have submitte...

I am pleased to report several changes at the IEEE Transactions on Software Engineering that will make the processing of papers more timely and more effective. First, we have removed the length restriction on submitted manuscripts. This should allow authors to document results in appropriate length papers. Despite the change, authors are encouraged to keep papers as short as possible. Second, w...

Bovine spongiform encephalopathy (BSE) and chronic wasting disease (CWD) of deer and elk are a threat to agriculture and natural resources, as well as a human health concern. Both diseases are transmissible spongiform encephalopathies (TSE), or prion diseases, caused by autocatalytic conversion of endogenously encoded prion protein (PrP) to an abnormal, neurotoxic conformation designated PrPsc....

RATIONALE Tonic status epilepticus (TSE) in patients with idiopathic generalized epilepsy (IGE) is not well recognized. The objective of this study is to report episodes of TSE in patients with IGE. METHODS We retrospectively reviewed the clinical and EEG evaluation of three IGE patients who presented TSE. RESULTS The three patients had mainly clinical features of IGE, but had developed, in...

With the introduction of Windows NT, Terminal Server Edition (TSE), Microsoft finally brings to Windows the “thin-client” computing model the X Window System has offered Unix for a decade. TSE’s two most salient features are the provision of multi-user login service and the provision of that service remotely, over a network link. These features distinguish TSE from previous Microsoft operating ...

Since the appearance in 1986 of epidemic of bovine spongiform encephalopathy (BSE), a new form of neurological disease in cattle which also affected human beings, many diagnostic and research activities have been performed to develop detection and therapeutic tools. A lot of progress was made in better identifying, understanding and controlling the spread of the disease by appropriate monitorin...

The term ‘‘prion’’ was originally coined by Prusiner to explain the unusual infectious agent in transmissible spongiform encephalopathies (TSEs, also known as prion disease) [1]. Now the term has expanded to include a growing list of fungal proteins that stably maintain an atypical self-propagating conformation and epigenetically modify a variety of cellular processes [2]. Although fungal prion...

BACKGROUND Addressing children's tobacco smoke exposure (TSE) remains a public health priority. However, there is low uptake and ineffectiveness of treatment, particularly in low-income populations that face numerous challenges to smoking behavior change. A multilevel intervention combining system-level health messaging and advice about TSE delivered at community clinics that disseminate the Sp...