نتایج جستجو برای: tsc and tcrfc compensators

تعداد نتایج: 16827505  

2017
David N. Franz Jamie K. Capal

Tuberous sclerosis complex (TSC) is a rare autosomal dominant genetic disorder that affects multiple organ systems throughout the body. Dysregulation of the mammalian target of rapamycin (mTOR) pathway is implicated in the disease pathology, and evidence exists to support the use of mTOR inhibitors in treatment. The mTOR pathway has also been investigated as a potential treatment target for sev...

Journal: :Medicina oral, patologia oral y cirugia bucal 2011
Karmen Harutunian Rui Figueiredo Cosme Gay-Escoda

INTRODUCTION Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome produced by a number of genetic mutations. The disease is characterized by the development of benign tumors affecting different body systems. The most common oral manifestations of TSC are fibromas, gingival hyperplasia and enamel hypoplasia. CLINICAL CASE A 35-year-old woman diagnosed with TSC presented with a reactiv...

2017
Tanjala T Gipson Michael V Johnston

Tuberous sclerosis complex (TSC) is a multi-system disorder resulting from mutations in either the TSC1 or TSC2 genes leading to hyperactivation of mechanistic target of rapamycin (mTOR) signaling. TSC is commonly associated with autism (61%), intellectual disability (45%), and behavioral, psychiatric, intellectual, academic, neuropsychological, and psychosocial difficulties that are collective...

Journal: :Journal of medical genetics 1997
J A Rodriguez R L Evans S P Daiger H Northrup

Group specific component (Gc) is an abundant plasma protein whose functional role is not clearly established. Gc protein is synthesised in the liver and is known to bind vitamin D, vitamin D metabolites, and G actin; Gc protein is also implicated in macrophage activation. Several polymorphic electrophoretic variants of Gc protein are found in all human populations; the most common alleles are G...

2002
X. Alex Wang

We give a new sufficient condition for the arbitrary pole assignability of a system by decentralized dynamic compensators. Using such condition we are able to derive a new bound on the degrees of decentralized dynamic compensators so that the generic systems have the arbitrary pole assignability.

2001
Hae-Seong Yoon Terrence J. Monks Jeffrey I. Everitt Cheryl L. Walker Serrine S. Lau

Although , 2,3,5-tris-(glutathion-S-yl)hydroquinone [(TGHQ) 2.5 μmol/kg, ip] markedly increased cell proliferation within the outer stripe of the outer medulla (OSOM) of the kidney in both Tsc-2 and Tsc-2 rats, only TGHQ-treated Tsc-2 rats developed renal tumors, indicating that cell proliferation per se was not sufficient for tumor development. Tuberin expression was initially induced within t...

2017
Michael A Cardis Cynthia Marie Carver DeKlotz

Tuberous sclerosis complex (TSC) is a multisystem genetic disorder stemming from unregulated activation of the mammalian target of rapamycin (mTOR) pathway, resulting in the growth of hamartomas in multiple organs. TSC-related skin lesions often develop early in life and can be disfiguring, emotionally distressful and even painful at times. Recognition of TSC-associated skin features by paediat...

2014
Juanjuan Liang Huimin Gao Liangmian Chen Wei Xiao Zhenzhong Wang Yongyan Wang Zhimin Wang

Chemical profiling is always the first task in the standardization and modernization of Traditional Chinese Medicine. HPLC and LC-MS were employed to find out the common chromatographic peaks in various batches of Tianshu Capsule (TSC) and the contribution of the characteristic peaks from individual herbs to the whole chromatographic profile of TSC sample. A total of 38 constituents were identi...

2013
Romina Moavero Antonella Coniglio Francesco Garaci Paolo Curatolo

Tuberous sclerosis complex (TSC) is a genetic multisystem disorder characterized by the development of hamartomas in several organs. Mutations in the TSC1 and TSC2 tumor suppressor genes determin overactivation of the mammalian target of rapamycin (mTOR) signaling pathway and subsequent abnormalities in numerous cell processes. As a result, mTOR inhibitors such as sirolimus and everolimus have ...

2003
Panayiotis D. Papadimitriou Costas N. Georghiades

It has been shown that signature (multi-) sets that meet Welch’s lower bound on the total squared correlation (TSC), maximize the sum capacity of the synchronous code division multiple access (CDMA) channel with equal average input energy constraints. However, a signature set that is TSC-optimum (i.e. achieves the lower bound on TSC), doesn’t necessarily have a low cross-correlation spectrum. H...

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