Hyperalgesia is a common clinical phenomenon among opioid dependent patients on methadone maintenance therapy (MMT) and it may be associated with undertreated pain and/or therapeutic failure. This study aimed to investigate association between serum methadone concentration (SMC) and cold pressor pain responses. Cold pressor pain responses in 147 opioid dependent patients on MMT were assessed us...

The relationship between nevirapine plasma concentrations and the durability of both viral suppression (VS) and selection of nevirapine primary resistance mutations (PRMs) was evaluated. A nevirapine trough concentration (Ctrough) of >4,300 ng/ml was found to predict longer VS. Patients with nevirapine Ctrough s ranging from 3,100 to 4,300 ng/ml had higher probabilities of developing PRMs than ...

OBJECTIVES The aim of this study was to develop and validate a population pharmacokinetic model for nevirapine in a population of HIV-infected adults and to evaluate the influence of nevirapine dosing regimen and patient characteristics on nevirapine trough concentration. METHODS HIV-infected adults receiving oral nevirapine for at least 4 weeks were included. A concentration-time profile was...

OBJECTIVE To estimate the intraocular pressure (IOP) reduction achieved by the most frequently prescribed glaucoma drugs and a placebo in a meta-analysis of randomized clinical trials. DESIGN Meta-analysis of randomized clinical trials. PARTICIPANTS Twenty-seven articles reporting on 28 randomized clinical trials. These articles reported 6953 participants for the trough and 6841 for the pea...

The bowl-championship-series (BCS) committee uses 10 ranking schemes, including eight computer rankings, to select college football teams for bowl-championship-series bowl games, including the national championship game. The large financial benefits of participating in BCS bowl games make it imperative that the selection process accurately select the best teams. I evaluated the performance of t...

OBJECTIVE To describe the relationships between dosing strategy, age, and vancomycin trough concentrations in pediatric patients. METHODS This is a retrospective review of hospitalized pediatric patients between 2 months and 17 years of age treated with intravenous vancomycin from 2008 to 2011. The primary outcome was the number of patients achieving a target trough concentration of 10 to 20 ...

Infrared (IR) and ultraviolet (UV) spectroscopic analysis of eight structural isomers of C20 carbon nanostructures, i.e. ring, tadpole, bow-tie, dumb-bell, spiro, propellane, bowl and cage, were performed at different levels of theory including semi-empirical (AM1 and PM3), Hartree-Fock (HF/6-31++G, 6-31++G**) and density functional theory (B3LYP/6-31++G, 6-31++G**). A broad range of IR spectra...

This paper reports a simple self-assembly strategy towards bowl-shaped carbon-containing hollow particles, as well as an unprecedented potential application for block copolymer vesicles in energy storage. Kippah vesicles (fully collapsed vesicles), formed by solution self-assembly of an amphiphilic polystyreneblock-poly(ethylene oxide) block copolymer, were employed as the template to guide the...