OBJECTIVES Oral tacrolimus administration is the common route of drug delivery. Recent studies suggest sublingual administration of tacrolimus as an alternative route may produce comparable drug trough levels with similar or even lower doses than the oral route, especially in lung transplant recipients; however, most of this research does not encompass intraindividual variations compared betwee...

The diurnal and seasonal variations of the northern Australian dryline are examined by constructing climatologies of low-level dynamic and thermodynamic variables taken from the high-resolution Australian Bureau of Meteorology’s Limited Area Prediction Scheme (LAPS) forecasts from 2000 to 2003. The development of the dryline is analyzed within the framework of the frontogenesis function applied...

[1] We use simultaneous global observations of the mid-latitude trough and the plasmapause to experimentally prove a long-standing conjecture of magnetosphereionosphere couplingnamely the mid-latitude trough and plasmapause are on the same field line. Global Ionospheric Maps (GIM), generated using ground based GPS receivers, are used to detect the globally extended mid-latitude trough; while gl...

INTRODUCTION When darunavir (DRV) 800 mg is boosted with 150 mg cobicistat (DRVcobi ), DRV trough concentration (Ctrough ) is about 30% lower as compared to 100 mg ritonavir (DRVrtv ). DRVcobi shows similar virological efficacy as DRVrtv when combined with two nucleos(t)ide analogue reverse-transcriptase inhibitors, but it is unknown whether a lower DRV Ctrough would undermine the effectiveness...

After orthotopic liver transplantation (OLT) many patients use emulsified cyclosporine. Recent data showed that blood levels 2 hours after dosing (C-2) better reflect systemic exposure to the drug (area under the blood concentration time curve) than trough levels (C-0) do. We investigated difference in dosage, creatinine clearance (CrCl), blood pressure (BP), freedom from rejection, and relatio...