The dual radionuclide myocardial distributions of imaging agents potassium43 (49K) and technetium-99m stannous pyrophosphate ('9mTc-PYP) were studied in a 24-hour closed chest canine infarct preparation. In multiple myocardial biopsies in 20 dogs, tissue levels of both radionuclides were compared to either an index of tissue viability (myocardial creatine phosphokinase [CPK] depletion), or to e...

Several radionuclides in a variety of chemical forms have been used for spleen scanning (1). None of these has as desirable physical properties as tech netium-99m, namely, the clean 140 keV gamma, absence of particulate radiation, and short physical half-life (2). As a result, it would be desirable to find a com pound of “9―Tc that could be used for spleen scanning. Technetium-99m sulfur co...

To study the scintigraphic detectability of cardiac rejection, we performed 135 planar myocardial scans ([99mTc]pyrophosphate, 85; 201Tl, 36; 67Ga, 14) together with endomyocardial biopsies in ten patients for a (mean) 17-mo postoperative period. Specificity of each agent exceeded 89%. Technetium-99m pyrophosphate showed results that significantly correlated with the severity of rejection (p = ...

Leukocytes labeled with technetium-99m using pretinning with stannous complexes of pyrophosphate, glucoheptonate, and gentisic acid were compared with respect to labeling efficiency, time required for labeling, in vitro cell viability, initial lung transit, and image quality following reinjection into normal volunteers. Gentisic acid pretinning was the best method, offering the shortest prepara...

The recent development of the instantaneously sensing Anger scintillation camera, capable of recording wide-field radioisotope images from the precordium, and a system for video storage and analysis has provided a means of visualizing the anatomic and hemodynamic features of the heart and great vessels without the hazards involved in introducing a radiopaque agent. Sodium pertechnetate (ODmTc04...

To compare the myocardial uptake pattern of 99mTc-labeled methoxyisobutyl isonitrile [( 99mTc] MIBI) and 201TI, planar scintigraphy were performed in both patients with documented coronary artery disease and subjects with a low likelihood of disease. Quantitative analysis was employed using a standard interpolative background subtraction algorithm and a new algorithm modified to better accommod...

This study evaluates the effects of an acute treatment with a Centella asiatica (CA) extract on the biodistribution of the radiopharmaceutical NaTcO4 and on the fixation of technetium-99m on blood constituents. Wistar rats were treated with CA extract and, 1 hour after, NaTcO4 was administered; organs/tissues were withdrawn and weighted. The radioactivity was counted to calculate the percentage...

UNLABELLED Technetium-99m dimercaptosuccinic acid (Tc-99m DMSA) as a static renal agent is currently the most frequently used agent in the detection of renal scarring, and allows accurate calculation of differential renal function (DRF). But this agent has some disadvantages such as relatively higher radiation dose and time consumption. METHODS The purpose of this study was to evaluate the po...

Electrocardiogram gated single photon emission computed tomography of the intracardiac blood pools is a recent development that involves the acquisition of images in multiple projections after in vivo erythrocyte labelling with technetium-99m and reconstruction of these images into tomographic sections in any desired plane. The technique was used in 25 subjects to measure left ventricular volum...

greatly facilitated by technetium-99m (99mTc)tracers, having comparable avid uptake and prolonged reten tion in the brain as the iodine-123-('231) labeled amines, isopropylamphetamine (IMP) and hydroxy benzyl-propanediamine (HIPDM). Such molecules would facilitate cerebral blood flow (CBF) tomography by conventional single photon emission computed to mography (SPECT). Technetium-99m is inexpens...