context triple negative breast cancer (tnbc) is a heterogeneous group of diseases that is negative for esterogen receptor (er) progesteron receptor (pr) and human epidermal growth factor receptor 2 (her2). this type of breast cancer is typically high-grade carcinomas, although low-grade tumors occur. the aim of this review is to focus on molecular classification and features, prognostic markers...

Dexlansoprazole MR is the R-enantiomer of lansoprazole that is delivered by a dual delayed release formulation. It is effective for symptom control of patients with gastroesophageal reflux disease. However, its efficacy in the treatment of Helicobacter pylori infection remains unclear. This pilot, randomized, controlled, head-to-head study was conducted to investigate whether the efficacy of si...

INTRODUCTION The aim of the present study was to evaluate the 24-h efficacy, tolerability, and ocular surface health with preservative-free (PF) tafluprost and a PF triple drug regimen comprising tafluprost and dorzolamide/timolol fixed combination (DTFC) in open-angle glaucoma patients who were insufficiently controlled with preserved branded or generic latanoprost monotherapy and who exhibite...

BACKGROUND Helicobacter pylori (H.pylori) infection causes multiple upper gastrointestinal diseases but optimal therapeutic regimen which can eradicate infection in all the cases has not yet been defined. This study was designed to evaluate the efficacy of triple levofloxacin-based versus clarithromycin-based therapy. METHODS In this open-label randomized clinical trial study 120 patients who...

INTRODUCTION Response to antiretroviral therapy (ART) among individuals infected with HIV-2 is poorly described. We compared the immunological response among patients treated with three nucleoside reverse-transcriptase inhibitors (NRTIs) to boosted protease inhibitor (PI) and unboosted PI-based regimens in West Africa. METHODS This prospective cohort study enrolled treatment-naïve HIV-2-infec...

OBJECTIVES We evaluated safety and efficacy of triple antiplatelet therapy with aspirin, clopidogrel, or ticlopidine and cilostazol after coronary stenting. BACKGROUND Triple antiplatelet therapy might have beneficial effect to prevent thrombotic complications in patients undergoing coronary stenting. METHODS Patients undergoing successful coronary stenting were divided into dual antiplatelet t...

OBJECTIVES We evaluated safety and efficacy of triple antiplatelet therapy with aspirin, clopidogrel, or ticlopidine and cilostazol after coronary stenting. BACKGROUND Triple antiplatelet therapy might have beneficial effect to prevent thrombotic complications in patients undergoing coronary stenting. METHODS Patients undergoing successful coronary stenting were divided into dual antiplatel...

Interim results of the C-WORTHY trial of the nonstructural (NS) 3/4A protease inhibitor MK-5172 and the NS5A replication complex inhibitor MK-8742 suggest that the combination exerts robust virologic suppression in treatment-naive patients with genotype (GT) 1 hepatitis C virus (HCV) infection. Interim results of C-WORTHY, a phase 2b trial, were reported by Eric Lawitz, MD, of the University of...

Helicobacter pylori infection is one of the most common infections in human worldwide. Chronic infection of H. pylori leads to multiple alimentary diseases including gastric inflammation, atrophic gastritis, peptic ulcer, gastric cancer and gastric mucosa-associated lymphoid-tissue (MALT) lymphoma. Prevalence of H. pylori infection rate has geographic variation which there is a higher prevalenc...

Helicobacter pylori (HP) are a bacterium that infects the mucus lining of the human stomach. HP has emerged as one of the most common bacterial pathogens worldwide . It is estimated that about half the world’s population is infected with HP . Curing the infection has the best outcome and is clearly the most cost effective management strategy for HP infected patients with ulcer disease . The goa...