نتایج جستجو برای: trinucleotide
تعداد نتایج: 1983 فیلتر نتایج به سال:
The two most consistent features of the diseases caused by trinucleotide repeat expansion-neuropsychiatric symptoms and the phenomenon of genetic anticipation-may be present in forms of dementia, hereditary ataxia, Parkinsonism, bipolar affective disorder, schizophrenia and autism. To identify candidate genes for these disorders, we have screened human brain cDNA libraries for the presence of g...
Development of gene expression prediction systems from huge amount of microarray data is an inevitable problem. In the present study a support vector machine (SVM) based method has been developed to predict expression of genes from its nucleotide sequence. In this method, SVM was trained on microarray data of genes and trained SVM was used to predict the expression of other genes of the same or...
Previous studies have examined DNA methylation in different trinucleotide repeat diseases. We have combined this data and used a pattern searching algorithm to identify motifs in the DNA surrounding aberrantly methylated CpGs found in the DNA of patients with one of the three trinucleotide repeat (TNR) expansion diseases: fragile X syndrome (FRAXA), myotonic dystrophy type I (DM1), or Friedreic...
In the past 3 years, a novel class of pathogenic mutation has seized the attention of geneticists. Socalled 'dynamic mutations', caused by expanding trinucleotide repeats, are responsible for the pathogenesis of a growing list of disorders, including fragile X syndrome and Huntington's disease. In addition to a shared molecular mechanism, trinucleotide repeat diseases also share a number of cli...
Highly polymorphic and transferable microsatellites (SSRs) are important for comparative genomics, genome analysis and phylogenetic studies. Development of novel species-specific microsatellite markers remains a costly and labor-intensive project. Therefore, interest has been shifted from genomic to genic markers owing to their high inter-species transferability as they are developed from conse...
We develop here an analytical evolutionary model based on a trinucleotide mutation matrix 64 x 64 with nine substitution parameters associated with the three types of substitutions in the three trinucleotide sites. It generalizes the previous models based on the nucleotide mutation matrices 4 x 4 and the trinucleotide mutation matrix 64 x 64 with three and six parameters. It determines at some ...
We have identified quencher-free molecular beacons that allow the sensitive probing of CAG repeat oligonucleotides, including mRNA fragments of trinucleotide repeat diseases, with significant increases in fluorescence intensity mediated by disruption of the stacking of their (Py)U units.
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