A complementary DNA (cDNA) clone (B4) encoding the catalytic subunit of a cAMP-dependent protein kinase (PKAc) was isolated from a XgtlO rat brain cDNA library, using a synthetic oligonucleotide probe whose sequence was based on the known amino acid sequence of a bovine cardiac PKAc. Sequence analysis of this clone revealed a region of 1002 nucleotides which encodes a protein that is 92% homolo...

exact mechanism(s) underlying CR-induced cardioprotection remain(s) unknown. Recent evidence indicates that Sirtuins, NAD ؉-dependent deacetylases, regulate various favorable aspects of the CR response. Thus, we hypothesized that deacetylation of specific mitochondrial proteins during CR preserves mitochondrial function and attenuates production of reactive oxygen species during ischemia/reperf...

lease has been proposed as a mechanism of activity-dependent changes in neurotransmitter release (Herring-to Birdsong ton et al., 1996; Tang and Zucker, 1997). Mitochondrial uptake and release of Ca 2ϩ was inconsistently observed in Mb1 synaptic terminals, and it typically required high (Ͼ800 nM) cytosolic Ca 2ϩ (Zenisek and Matthews, 2000). A basic principle of functional brain organization is...

Copyright © 2012 Muthuswamy Balasubramanyam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Diabetes mellitus is a metabolic disease caused by both genetic and environmental factors. The pathogenic mech-anism(s) of diabetes...

This paper reports our continuing e orts and initial results with the problem of admission control in real time networks This problem was rst addressed by the Tenet group and their approach was based on the assumption that the link level scheduling was EDD Earliest Due Date based Our work departs from this assumption by addressing the problem in the context of any arbit rary dynamic xed priorit...

We develop efficient algorithms to construct utility maximizing mechanisms in the presenceof risk averse players (buyers and sellers) in Bayesian single parameter and multi-parametersettings. We model risk aversion by a concave utility function, and players play strategically tomaximize their expected utility. Bayesian mechanism design has usually focused on maximizingexpect...

Grassi, Silvarosa, Ermelinda Francescangeli, Gianfrancesco anism, as mGluRs are greatly implied in increasing the glutaGoracci, and Vito E. Pettorossi. Role of platelet-activating factor mate release (Pin and Duvoisin 1995). The possible exisin long-term potentiation of the rat medial vestibular nuclei. J. tence of presynaptic mechanisms at vestibular level leads us Neurophysiol. 79: 3266–3271,...

the calcitriol–receptor complex with target genes [8] Introduction and a recently revealed decrease of retinoid-X receptor density [9]. As renal failure progresses, this disturbance High turnover bone disease remains one of the central may form a vicious cycle of further reducing calcitriol features of renal osteodystrophy seen in chronic dialysis receptor density leading to progressive resista...

We efficiently solve the optimal multi-dimensional mechanism design problem for independentbidders with arbitrary demand constraints when either the number of bidders is a constantor the number of items is a constant. In the first setting, we need that each bidder’s valuesfor the items are sampled from a possibly correlated, item-symmetric distribution, allowingdifferent distrib...

At 4°C transferrin bound to receptors on the reticulocyte plasma membrane, and at 37°C receptor-mediated endocytosis of transferrin occurred. Uptake at 37°C exceeded binding at 4°C by 2.5-fold and saturated after 20-30 min. During uptake at 37°C, bound transferrin was internalized into a trypsin-resistant space. Trypsinization at 4°C destroyed surface receptors, but with subsequent incubation a...