BACKGROUND Patients with high levels of total cholesterol (TCH), low-density lipoprotein cholesterol (LDL-CH), and triglyceride (TG) are at increased risk of coronary heart disease. Studies have shown that flavonoids and antioxidant compounds have beneficial effects on hyperlipidemia. OBJECTIVES The aim of the present study was to evaluate the effects of extract of Hypericum perforatum (EHP) ...

Familial combined hyperlipidemia (FCHL, MIM-144250) is a common, multifactorial and heterogeneous dyslipidemia predisposing to premature coronary artery disease and characterized by elevated plasma triglycerides, cholesterol, or both. We identified a mutant mouse strain, HcB-19/Dem (HcB-19), that shares features with FCHL, including hypertriglyceridemia, hypercholesterolemia, elevated plasma ap...

This study aimed to analyze the effects and potential mechanisms of pioglitazone on triglyceride and cholesterol metabolism in obese diabetic KKAy mice. Pioglitazone was orally administered to KKAy mice over 30 days. Compared to C57BL/6J mice, KKAy mice developed obvious insulin resistance, hepatic steatosis, and hyperlipidemia. Pioglitazone treatment resulted in deteriorated microvesicular ste...

Apolipoprotein E3-Leiden (APOE*3-Leiden) transgenic mice have been studied to identify factors modulating chylomicron and VLDL remnant lipoprotein metabolism. Transient elevated levels of VLDL/LDL-sized lipoproteins occurred in these mice with maximal levels during the period of rapid growth (optimum at 45 d of age). After about 100 d of age, serum cholesterol and triglyceride levels stabilized...

In Qatar, laparoscopic gastric sleeve (LGS) is a key surgical method for obesity treatment. This study assessed its impact on the lipid profiles of 863 obese patients, some with hyperlipidemia. Spanning five years (2015-2020), research monitored metrics like total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and high-density (HDL). Post-LGS, TC, LDL levels decreased after...

because the ingestion of some types of dietary fibers has been shown to influence on the lipid and lipoprotein levels, it is possible that chitosan influences on lipid metabolism. in the present study, the effects of chitosan on the serum, liver lipid and lipoprotein concentrations in rat were investigated. serum lipid level in the treatment groups were decreased compared to that of the control...

Nuclear receptor transcription factors are ligand-activated proteins that control various biological events from cell growth and development to lipid metabolism, and energy and glucose homeostasis. Nuclear receptors are important drug targets for metabolic diseases. Liver X receptors (LXRs) are nuclear receptor transcription factors that play essential roles in regulation of cholesterol, trigly...

CE Full-text articles and CE testing at CompendiumVet.com.Send comments/ questions via email compendium@ medimedia.com, fax 800-556-3288, or web CompendiumVet.com. Lipid disorders are common in dogs, with most arising from secondary causes such as endocrine imbalances, cholestatic liver disease, or protein-losing nephropathies.Two primary lipid disorders—idiopathic hyperlipidemia in miniature s...

We describe an electroimmunodiffusion technique for measuring /3-lipoprotein in cord blood spotted on filter paper. A series of cord-blood samples, taken from 916 consecutive live-birth infants, was spotted directly onto filter paper and assayed for /3-lipoprotein. Eleven had abovenormal /3-lipoprotein. Of these 11, seven were tested two to six months later, along with their parents, for total ...