Clinical Indicators of Extracranial Carotid Artery Disease in Patients With Transient Symptoms • The clinical findings in 64 patients with transient symptoms of unilateral carotid system ischemic disease (amaurosis fugax or transient focal cerebral ischemic attacks or both) were reviewed in an effort to determine the value of the neurovascular examination in predicting the presence and extent o...

BACKGROUND Ischemic postconditioning (IPOC), or relief of ischemia in a stuttered manner, has emerged as an innovative treatment strategy to reduce programmed cell death, attenuate ischemic injuries, and improve neurological outcomes. However, the mechanisms involved have not been completely elucidated. Recent studies indicate that autophagy is a type of programmed cell death that plays elusive...

OBJECTIVE Cardiac diseases are established risk factors for ischemic stroke incidence and severity. Conversely, there is increasing evidence that brain ischemia can cause cardiac dysfunction. The mechanisms underlying this neurogenic heart disease are incompletely understood. Although it is established that ischemic stroke is associated with cardiac arrhythmias, myocardial damage, elevated card...

BACKGROUND AND PURPOSE In contrast to early hypothermia, the effects of delayed hypothermia in focal cerebral ischemia have not been widely addressed. We examined the influence of delayed hypothermia on secondary ischemic injury, MRI lesion size, and neurological outcome after transient focal cerebral ischemia in a rat model. METHODS Rats (n=30) were subjected to transient middle cerebral art...

BACKGROUND AND PURPOSE Our previous study has demonstrated that the rapid tolerance to cerebral ischemia by electroacupuncture (EA) pretreatment was possibly mediated through an endocannabinoid system-related mechanism. The purpose of this study was to investigate whether activation of epsilon protein kinase C (εPKC) was involved in EA pretreatment-induced neuroprotection via cannabinoid recept...

“Stroke” is defined as rapid onset of focal neurological deficit, resulting from diseases of the cerebral vasculature and its contents. The term “transient ischemic attacks” (TIA) implies warning symptoms of stroke usually lasting upto 30 minutes to one hour, and complete recovery within 24 hours. Second TIA often causes more damage than the first. Without proper treatment one out of ten subjec...

Objective: Cerebral ischemic stroke is a life threatening neurological disorder leads to mortality and long term disability in survival patients. Atherosclerosis is a common cause of ischemic strokes which inturn predisposes thromboembolism and than triggers thrombotic strokes or transient ischemic attacks. The atherogenic nature of homocysteine plays a vital role in the development of cardiac ...

detection and modification of the risk factors of stroke may be the most effective strategy for preventing its often irreversible consequences. a longitudinal prospective study was implemented to evaluate the effect of several risk factors on the course of cerebrovascular disease. the study groups were composed of 3s8 normal volunteers, and 308 patients with transient ischemic attacks. the two ...

Objective(s): Stroke poses a crucial risk for mortality and morbidity. Our study aimed to investigate the effect of p-coumaric acid on focal cerebral ischemia in rats. Material and Methods: Rats were randomly divided into four groups, namely Group I (control rats), Group II (ischemia rats), Group III (6 hr ischemia + p-coumaric acid rats) and Group IV (24 hr ischemia + p-coumaric acid rats). C...