In this paper we portrait Model Driven Architecture (MDA) as an approach to derive products in a particular class of software product families, i.e. a configurable product family. The main contribution of this paper is that we relate MDA to a configurable software product family and discuss the mutual benefits of this relation. With respect to variability management, we identify two main benefi...

BACKGROUND Trichoepithelioma is a rare benign skin lesion that originates from hair follicles. Trichoepitheliomas are mostly seen in the scalp, nose, forehead, and upper lip. METHODS We present a large family of Iranian origin with 15 individuals affected with multiple familial trichoepithelioma in four generations, and treated with three different methods. RESULTS Trichoepithelioma is his...

Constructing skew and heavy-tailed distributions by transforming a standard normal variable goes back to Tukey (1977) and was extended and formalized by Hoaglin (1983) and Martinez & Iglewicz (1984). Applications of Tukey’s GH distribution family – which are composed by a skewness transformation G and a kurtosis transformation H – can be found, for instance, in financial, environmental or medic...

This paper shows how the Improvement Theorem|a semantic condition for establishing the total correctness of program transformation on higher-order functional programs|has practical value in proving the correctness of automatic techniques. To this end we develop and study a family of automatic program transformations. The root of this family is a well-known and widely studied transformation call...

The analysis for a given Soft-Switching DC-DC converter family can be generalized using the switching-cell of that family leading to a number of generalized equations with a Transformation Table. In this paper, the concept of generalization and step by step procedure for the generalized process are discussed and applied to selected soft-switching families such as ZVS-QRC, ZCS-QRC, ZCS-CC QSW,ZV...

This paper presents a solution to the Families to Persons case at the Transformation Tool Contest (TTC) 2017 using the .NET Modeling Framework (NMF). The goal of this case was to bidirectionally synchronize a simple model of family relationships with a simple person register. We propose a solution based on the bidirectional and incremental model transformation language NMF Synchronizations.

In this paper we describe a solution for the Transformation Tool Contest 2014 (TTC'14) FIXML case study using SIGMA, a family of Scala internal Domain-Specific Languages (DSLs) that provides an expressive and efficient API for model consistency checking and model transformations. We solve both the core transformation task and its three extensions.

The HMG-I gene family encodes high mobility group proteins originally identified as nonhistone chromosomal binding proteins. HMG-I and -Y proteins are alternatively spliced products of the same mRNA; HMG-C is encoded by a separate gene. The HMG-I proteins function as architectural chromatin-binding proteins that bind to the narrow groove of AT-rich regions in double-stranded DNA. Recent studies...

Cellular transformation can be achieved by constitutive activation of growth-regulatory signaling pathways, which, in turn, activate nuclear transcription factors thought to execute a transformation-specific program of gene expression. Members of the dimeric transcription factor family AP-1 are at the receiving end of such growth-regulating pathways and the viral form of the AP-1 subunit Jun es...