A matrix-type transdermal therapeutic system was developed for treating diseases of the eye where it is difficult for drug molecules to reach with conventional topical instillation. Prednisolone was employed as a model drug. An in vivo study using rats showed that the daily application of the patch maintained a constant plasma concentration of the drug, which was equivalent the therapeutic plas...

BACKGROUND Microneedle-mediated drug delivery is a promising method for transdermal delivery of insulin, incretin mimetics, and other protein-based pharmacologic agents for treatment of diabetes mellitus. One factor that has limited clinical application of conventional microneedle technology is the poor fracture behavior of microneedles that are created using conventional materials and methods....

Over many millennia, natural products were the only means for food, to treat diseases and injuries. Recently in the field of pharmaceutical sciences great efforts are being directed towards herbal drugs by incorporating them in already existed drug delivery system to solve the problem related to poor solubility, poor bioavailability, dosing problem, stability, toxicity etc. Curcumin is a yellow...

The objective of this study was to assess the transdermal delivery of drugs using iontophoresis with cation- and anion-exchange fibers as controlled drug delivery vehicles. Complexation of charged model drugs with the ion-exchange fibers was studied as a method to achieve controlled transdermal drug delivery. Drug release from the cation-exchange fiber into a physiological saline was dependent ...

The skin offers an accessible and convenient site for the administration of medications. To this end, the field of transdermal drug delivery, aimed at developing safe and efficacious means of delivering medications across the skin, has in the past and continues to garner much time and investment with the continuous advancement of new and innovative approaches. This review details the progress a...

Chest wall tuberculosis (TB) is an endemic disease with a large number of variants. The condition affects numerous parts of the body and can penetrate the skin to form chronic open ulcers. Current treatment methods include oral anti-TB drugs and surgery. However, conventional drug treatments are not effective due to the difficulty in achieving an effective local concentration, and certain patie...

Transdermal drug delivery offers several advantages, including avoidance of erratic absorption, absence of gastric irritation, painlessness, noninvasiveness, as well as improvement in patient compliance. With this mode of drug administration, there is no pre-systemic metabolism and it is possible to increase drug bioavailability and half-life. However, only a few molecules can be delivered acro...

Abstract Background Transdermal drug delivery is one of the most widely used administration routes, which offer several advantages over other routes delivery. The apical layer skin called stratum corneum dominant obstacle in transdermal delivery, restricts passage drugs across skin. Considerable strategies have been applied to enhance rate permeation epithelial cells; however, strategy use sorp...

The purpose of the present study was to develop a novel transdermal drug-delivery system comprising a polyamidoamine dendrimer coupled with sonophoresis to enhance the permeation of diclofenac (DF) through the skin. The novel transdermal drug-delivery system was developed by using a statistical Plackett-Burman design. Hairless male Wistar rat skin was used for the DF-permeation study. Coupling ...

Transdermal drug delivery systems (TDDS) are used to deliver the drug(s) or therapeutically active substances through topical route primarily skin. Relatively very small numbers of drugs administered transdermally because in many cases physical properties drugs, including polarity and molecular size, have limited its capacity particular dug transdermally. Now a day’s transdermal techniques vari...