Transcutaneous spinal cord stimulation (SCS) is a noninvasive method to electrically stimulate afferent structures of the human lumbar spinal cord. These are the same neural targets as predominantly activated by epidural implants. Biophysical principles derived from computer simulations contributed to the identification of the directly activated neural structures. These simulations combine fini...

Background Although neurostimulation has been shown to be of benefit in angina pectoris, the exact mechanism of its action is not clear. This study was performed to examine the effect of transcutaneous electrical nerve stimulation on coronary blood flow. Methods and Results The effect of transcutaneous electrical nerve stimulation was studied in 34 syndrome X patients (group 1), 15 coronary art...

The introduction of ondansetron has revolutionised the treatment of nausea and vomiting which frequently follows cisplatin and other drugs used in the treatment of cancer. However, there remain some patients for whom this 5 HT3 antagonist offers only a partial alleviation of symptoms, particularly on the 3rd and 4th days of treatment. Even when there may be no vomiting, some patients still rema...