نتایج جستجو برای: transannular interaction

تعداد نتایج: 565925  

Journal: :Journal of Synthetic Organic Chemistry, Japan 2012

2014
Gurjaspreet Singh

CH3(O)2SOSi(OC6H2Me2CH2)3N (1), CH3OSi(OC6H2Me2CH2)3N (2) and CH3(O)2SO.Si(OCH2CH2)3N (3) have been synthesized in high yield by the reaction of 1-isothiocyanatosilatranes with dimethyl sulfite and methyl methanesulfonate. These novel silatranes have been characterized by elemental analysis, infrared spectroscopy, 1 H, 13 C, 29 Si NMR spectroscopy and mass spectrometry. Semi-empirical quantum m...

Journal: :The Journal of organic chemistry 2010
Michael E Jung Ting-Hu Zhang Rebecca M Lui Osvaldo Gutierrez K N Houk

While thermolysis of the macrobicyclic triene lactone 12 did not produce the expected bicyclic transannular Diels-Alder (BTADA) product 13, heating the corresponding ether 18 to 110 °C for 4 h afforded a quantitative yield of the desired cycloadduct 19, which could be easily reduced to the perhydrophenanthrene, an ABC ring analogue of fusidic acid 1. Theoretical calculations with hybrid density...

Journal: :Organic & biomolecular chemistry 2013
Guilhem Chaubet Thibault Coursindel Xavier Morelli Stéphane Betzi Philippe Roche Yannick Guari Aurélien Lebrun Loïc Toupet Yves Collette Isabelle Parrot Jean Martinez

Access to diastereoisomeric forms of original spirolactam frameworks and investigation of their folded potentials are depicted here. Taking advantage of a stereoselective ring-contraction reaction, the Transannular Rearrangement of Activated Lactams (TRAL), followed by two unprecedented tandem reactions, we describe here an efficient access to elegant spirocyclic scaffolds. After dimerization, ...

Journal: :Tetrahedron letters 2008
Derek T Craft Benjamin W Gung

A 14-membered macrocycle with an allene and a furan strategically located at across the ring from each other is synthesized using an allene ring closing metathesis reaction. Upon treatment of the macrocycle with a catalytic amount of Pd(OAc)(2) and other additives, the first transannular [4+3] cycloaddition occurred to yield 37% of a tetracyclic compound containing the ABC ring structure of the...

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