Endogenous nitric oxide (NO) plays an important role in maintaining a vasodilator tone. In the present study, we compared the effects of NO blockade on the steady and pulsatile components of arterial hemodynamics between spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto strain (WKY), 22-26 wk of age. In the first series of experiments, various doses (1-30 mg/kg iv) of N G-nitr...

OBJECTIVE Persons with elevated blood pressure (BP) show dampened emotional responses to affect-laden stimuli. We sought to further examine cardiovascular-emotional dampening by examination of the relationship between resting hemodynamic measures and recognition of emotion in an African American community-based sample. METHODS Participants were 106 African American men and women (55 women; me...

We have previously shown that P2x purinoceptor activation in the subpostremal nucleus tractus solitarius (NTS) produces dose-dependent decreases in mean arterial pressure (MAP), heart rate, efferent sympathetic nerve activity, and significant peripheral vasodilation. However, the relative roles of cardiac output (CO) and total peripheral resistance (TPR) in mediating this depressor response are...

Mental stress can trigger myocardial infarction, with poor vascular responses to stress implicated as a pathway. Vascular stress reactivity can be assessed by different methods, such as total peripheral resistance (TPR) and forearm blood flow (FBF). Little is known about how these vascular assessments are linked. This was examined in two separate studies. Healthy men (Study 1: N = 29, Study 2: ...

Dead plant tissues and ash from a prescribed fire play an important role in nutrient balance and cycling in the Florida Everglades ecosystem. The objective of this study was to assess the dynamic changes in total phosphorus release (TPr) from ash or tissues of either cattail (Typha domingensis Pers.) or sawgrass (Cladium jamaicense Crantz) to water. Natural-dead (senesced-dead) and burning-dead...

OBJECTIVE Activation of thromboxane receptors (TPr) is implicated in atherosclerosis and inflammation. This study examined how activation of TPr modulates IL-1beta-induced vascular cell adhesion molecule (VCAM)-1 expression in aortic vascular smooth muscle cells (VSMCs). METHODS AND RESULTS In VSMCs, activation of TPr with U46619, a stable thromboxane A2 mimetic, alone did not induce VCAM-1 e...

progression or recurrence (TPR) in its clinical presentation and imaging findings in brain tumor patients. In this issue, Korchi et al describe imaging appearances of five consecutive cases of RN from 73 skull-based tumors treated with proton-beam radiotherapy (RT) in Switzerland.1 An important feature of this study is the selection of patients with extra-axial tumors that tend to recur locally...

Ideally, moving object databases should handle the past, current and future positions of moving objects efficiently. However, existing indexes such as SEB-Tree, SETI-Tree, 2+3R-Tree, 23RT-Tree and etc. can only provide the capability for past and current query, and the others such as TPR-Tree, and TPR*-Tree can only provide the capability for current and future query. None of them can provide a...

The TPR proteins FKBP52, FKBP51, Cyp40, and PP5 are found in steroid receptor (SR) complexes, but their receptor-specific preferences and roles remain unresolved. We have undertaken a systematic approach to this problem by examining the contribution of all four TPRs to the localization properties of glucocorticoid (GR) and progesterone (PR) receptors. The GR of L929 cells was found in the cytop...

The anaphase-promoting complex or cyclosome (APC/C) is a large E3 RING-cullin ubiquitin ligase composed of between 14 and 15 individual proteins. A striking feature of the APC/C is that only four proteins are involved in directly recognizing target proteins and catalyzing the assembly of a polyubiquitin chain. All other subunits, which account for >80% of the mass of the APC/C, provide scaffold...