PURPOSE To report the clinical outcomes with 24-month follow-up of transepithelial cross-linking using a combination of a D-alpha-tocopheryl polyethylene-glycol 1000 succinate (vitamin E-TPGS)-enhanced riboflavin solution and abbreviated low fluence UV-A treatment. METHODS In a nonrandomized clinical trial, 25 corneas of 19 patients with topographically proven, progressive, mild to moderate k...

BACKGROUND The aim of this study was to develop an optimized solid self-microemulsifying drug delivery system (SMEDDS) formulation for sirolimus to enhance its solubility, stability, and bioavailability. METHODS Excipients used for enhancing the solubility and stability of sirolimus were screened. A phase-separation test, visual observation for emulsifying efficiency, and droplet size analysi...

The aim of this research was to investigate synergistic effect combination two related antioxidant agents by novel synthesis selenium nanoparticles functionalized with D-α- Tocopherol polyethylene glycol 1000 succinate (TPGS) as a capping agent during chemical reduction sodium selenite ascorbic acid. Particle size, morphology, crystallite size synthesized Se-TPGS were characterized dynamic ligh...

Test pattern storage is an important problem aaect-ing all Design for Testability (DfT) techniques based on scan-path. Test compaction is the key idea to reduce this problem, but in case of partial-scan test compaction would concern the concatenation and overlapping of test sequences instead of test vectors. Unfortunately, standard sequential TPGs do not show suucient capabilities in test seque...

An environmentally benign surfactant (TPGS-750-M), a diester composed of racemic α-tocopherol, MPEG-750, and succinic acid, has been designed and readily prepared as an effective nanomicelle-forming species for general use in metal-catalyzed cross-coupling reactions in water. Several "name" reactions, including Heck, Suzuki-Miyaura, Sonogashira, and Negishi-like couplings, have been studied usi...

OBJECTIVES In situ formation of nanocrystals and dissolution profiles of fenofibrate (FFB) from a self-microemulsifying drug delivery system (SMEDDS) were characterized. METHODS SMEDDS formulated with Myritol and surfactant mixture (Smix) of D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) and either Tween 20 (A, C, E, G, M, S, N, T, O) or Tween 80 (B, D, F, H, P, U, Q, V, R) at vario...