A review on applicability of in silico methods for toxicity testing by calculation for regulatory purposes, their survey and background of QSAR (Quantitative Structure-Activity Relationships) analysis are presented.

Contemporary information on road salt runoff is needed for management of water resources in regions experiencing urbanization and increased road density. We investigated seasonal Cl(-) concentrations among five streams in south-central Indiana that drained watersheds varying in degree of urbanization and ranging in size from 9.3 to 27 km(2). We also conducted acute toxicity tests with Daphnia p...

Sediment toxicity tests are valuable tools for assessing the potential effects of contaminated sediments in dredged material evaluations because they inherently address complexity (e.g., unknown contaminants, mixtures, bioavailability). Although there is a need to understand the chronic and sublethal impacts of contaminants, it is common to conduct only short-term lethality tests in evaluations...

Selenium (Se) at high concentrations can cause toxic effects in plants, whereas at low concentrations it enhances resistance to certain abiotic stresses. The possible mechanisms of the Se-enhanced tolerance of plants to salinity stress remain elusive. In this work, effect of Se supplementation at 0, 0.1, 1 and 10 mg l-1 sodium selenate was studied in Lallemantia iberica plants subjected to salt...

In the present work we evaluated the antibacterial activity of Indian plants used in the Unani system of medicine against the pathogenic bacteria. The aqueous extracts of Tinospora cordifolia (stem), Sisymbrion irio (seeds), Viola odorata (flowers), Glycerrhiza glabra (roots and stolon) and Peristrophe bicalculata (whole plant) showed strong antibacterial activity against Salmonella typhi and E...

boron (b) toxicity is an important disorder that can limit plant growth in arid and semi-arid environments. it has been proven that use of tolerant rootstocks impede b uptake or transport to the aerial portions of plants. this may alleviate b toxicity in the scion, consequently improves the tolerance to excess b in the root zone. an experiment was conducted to find the effects of b toxicity on ...

Aqueous extracts of nine plants, known to have medicinal activity, were tested for their toxicity against the sweet potato whitefly, Bemisia tabaci Genn. (Homoptera: Aleurodidae) compared to the toxicity of the insecticide, Imidacloprid. Extracts of Lepidiuim sativum L. (Brassicales: Brassicaceae) killed 71 % of early stage nymphs, which was not significantly different from mortality caused by ...

Consensus Regarding new Drug Applications. " The Agency has revised this guidance based on comments it received on the proposed implementation. This approach, designed to facilitate the early stages of pharmaceutical development, is not and ICH consensus position although it is considered to be in general agreement with the ICH position on acute toxicity testing. This guidance was published in ...