نتایج جستجو برای: toxic proteins
تعداد نتایج: 625380 فیلتر نتایج به سال:
The most frequent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia is a G 4 C 2 repeat expansion in the C9orf72 gene. This gives rise to translation aggregating dipeptide (DPR) proteins, including poly-GA as abundant species. However, gain toxic function effects have been attributed either DPRs or pathological RNA. Here, we analyzed cellular model relative toxicity Cyt...
Sulfur mustard or mustard gas has been widely used as a chemical weapon in the first world war and Iraq-Iran war. It causes acute and chronic complications in lungs, eyes and skin. In skin, mustard is toxic, mutagenic, and carcinogenic via alkylation of cellular proteins in enzymes, cell membranes, cytoplasm and particularly cell nucleus as well as in DNA components of the epidermis, dermis and...
BACKGROUND: Multiple sclerosis (MS) is a demyelinating inflammatory disease of the central nervous system white matter. Both environmental and genetic factors have been implicated in its pathogenesis. Heavy metals generate free radicals causing alteration material blood-brain barrier damage. In addition, intracellular accumulation certain heavy can trigger autoimmune reaction against myelin pro...
Toxin production in algal blooms presents a significant problem for the water industry. Of particular concern is microcystin, a potent hepatotoxin produced by the unicellular freshwater species Microcystis aeruginosa. In this study, the proteomes of six toxic and nontoxic strains of M. aeruginosa were analyzed to gain further knowledge in elucidating the role of microcystin production in this m...
Industrial development may result in the increase of environmental risks. The enzymatic transformation of polluting compounds to less toxic or even innocuous products is an alternative to their complete removal. In this regard, a number of different redox enzymes are able to transform a wide variety of toxic pollutants, such as polynuclear aromatic hydrocarbons, phenols, azo dyes, heavy metals,...
Formation of aberrant protein conformers is a common pathological denominator of different neurodegenerative disorders, such as Alzheimer's disease or prion diseases. Moreover, increasing evidence indicates that soluble oligomers are associated with early pathological alterations and that oligomeric assemblies of different disease-associated proteins may share common structural features. Previo...
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