Drug-induced torsades de pointes (TdP) is common with class III antiarrhythmic drugs. Increased transmural dispersion of repolarization (TDR) contributes significantly to the development of TdP. Gap junctions play an important role in maintaining TDR in long QT syndrome. The present study examined the effect of a gap junction enhancer, antiarrhythmic peptide 10 (AAP10), on ibutilide-induced TdP...

BACKGROUND Loperamide is an over-the-counter, inexpensive, antidiarrheal opioid that can produce life-threatening toxicity at high concentrations. CASE REPORT 1: A 28-year-old man with a history of depression and substance abuse disorder (SUD) presented to the emergency department (ED) with shortness of breath and lightheadedness. He ingested large amounts of loperamide daily. The patient's ini...

n Rivaroxaban (Xarelto®) and reports of lack of efficacy in orthopaedic surgery indication ............................Page 8 Two recent research studies have strengthened the evidence regarding the potential risk of QT prolongation associated with the use of azithromycin. In the light of this latest data, healthcare professionals are advised to be aware of the risk of Torsades de Pointes and f...

BACKGROUND Restitution through intracardiac pacing has been used to assess arrhythmia vulnerability. We examined whether analyses of sequential beat-to-beat QT and TQ interval measures can be used to quantify ECG restitution changes under normal sinus rhythm. METHODS The QT, R-R and TQ intervals were examined 22.5 hour Holter monitoring before and after oral sotalol in normal male and female ...

Corresponding author: Marco Morosin MD Cardiovascular Deptartment Ospedali Riuniti Trieste Marco Morosin Via Valdoni 7 34149 Trieste, Italy Phone: +39 0403994477 E-mail: marco.morosin01@ gmail.com 1 Cardiovascular Department “Ospedali Riuniti” Trieste and Postgraduate School Cardiovascular Sciences, University of Trieste and Cardiology Department “Santa Maria degli Angeli” Hospital, Pordenone, ...

ZJUNlict have participated in Robocup for about nine years since 2004. In this paper, we summarizes the details of ZJUNlict robot soccer system we have made in recent years. we will emphasize the main ideas of designing in the robots’ hardware and our new software systems. Also we will share our tips on some special problems.

The glycosylation of natural product scaffolds with highly modified deoxysugars is often essential for their biological activity, being responsible for specific contacts to molecular targets and significantly affecting their pharmacokinetic properties. In order to provide tools for the targeted alteration of natural product glycosylation patterns, significant strides have been made to understan...

Cardiac toxicity may be associated with drugs used for malaria. Torsades de pointes (TdP) is a well-known adverse effect of quinidine when used for atrial fibrillation. Intravenous quinidine doses for resistant malaria are 2 to 3 times higher than those used for arrhythmias. Among 6 patients receiving quinidine for malaria or babesiosis, 4 developed QT interval prolongation and 2 experienced Td...

We describe the case of a teenager with a structurally normal heart that presented with torsades de pointes and cardiac arrest. He had a history of epilepsy in childhood, mild cognitive impairment and cognitive visual dysfunction. The baseline electrocardiogram had prominent J waves and a marked early repolarization pattern in all the leads, with normal QT interval. We discuss the differential ...