In this communication we draw attention on serious flaws that plague recently reported antioxidant properties of atorvastatin (ATV) in methanol. First and foremost, emphasize the O-H bond dissociation energies (BDE) about 400 kcal/mol previously are completely wrong. Further, present results refuting previous claim proton affinity (PA) ATV is smaller than ascorbic acid. That unfounded relies in...

Hypoxanthine is a mutagenic purine base that most commonly arises from the oxidative deamination of adenine. Damaged bases such as hypoxanthine are associated with carcinogenesis and cell death. This inevitable damage is counteracted by glycosylase enzymes, which cleave damaged bases from DNA. Alkyladenine DNA glycosylase (AAG) is the enzyme responsible for excising hypoxanthine from DNA in hum...

In protein environments, proton transfer reactions occur along polar or charged residues and isolated water molecules. These species consist of H-bond networks that serve as proton transfer pathways; therefore, thorough understanding of H-bond energetics is essential when investigating proton transfer reactions in protein environments. When the pKa values (or proton affinity) of the H-bond dono...

The concept of conditional stability constant is extended to the competitive binding of small molecules to heterogeneous surfaces or macromolecules via the introduction of the conditional affinity spectrum (CAS). The CAS describes the distribution of effective binding energies experienced by one complexing agent at a fixed concentration of the rest. We show that, when the multicomponent system ...

The addition of forward proton detectors to LHC experiments will significantly enlarge the potential for studying New Physics. A topical example is Higgs production by the central exclusive diffractive process, pp → p+H + p. We discuss the exclusive production of Higgs bosons in both the SM and MSSM. Special attention is paid to the backgrounds to the H → bb̄ signal. 1 Presented by V.A. Khoze at...

Background/aim Eosinophilic esophagitis (EoE) is a chronic immunemediated condition characterized clinically by esophageal dysfunction and pathologically by infiltration of > 15 eosinophils per high-powered field (HPF) in the esophageal mucosa, since other causes of esophageal eosinophilia (including proton-pump inhibitor responsive esophageal eosinophilia [PPI-REE]) are excluded. It occurs wor...

The TonB system of gram-negative bacteria energizes the active transport of diverse nutrients through high-affinity TonB-gated outer membrane transporters using energy derived from the cytoplasmic membrane proton motive force. Cytoplasmic membrane proteins ExbB and ExbD harness the proton gradient to energize TonB, which directly contacts and transmits this energy to ligand-loaded transporters....

In the photocycle of bacteriorhodopsin at pH 7, a proton is ejected to the extracellular medium during the protonation of Asp-85 upon formation of the M intermediate. The group that releases the ejected proton does not become reprotonated until the prephotolysis state is restored from the N and O intermediates. In contrast, at acidic pH, this proton release group remains protonated to the end o...

Synaptic activity causes significant fluctuations in proton concentrations in the brain. Changes in pH can affect neuronal excitability by acting on ligand-gated channels, including those gated by glutamate. We show here a subunit-dependent regulation of native and recombinant kainate receptors by physiologically relevant proton concentrations. The effect of protons on kainate receptors is volt...

Steady-state bacterial photosynthesis is modelled as cyclic chemical reaction and is examined with respect to overall efficiency, power transfer efficiency, and entropy production. A nonlinear flux-force relationship is assumed. The simplest two-state kinetic model bears complete analogy with the performance of an ideal (zero ohmic resistance of the P-N junction) solar cell. In both cases power...